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Inflammasomes are key innate immune system receptors that detect pathogenic
endo‑ and exogenous stressors like microorganisms or ultraviolet radiation (UVR)
which activate the highly proinflammatory cytokines interleukin‑1β and interleukin‑18.
F‑box and WD repeat domain‑containing protein 7 (FBW7), also known as FBXW7,
AGO or hCDC4, is an F‑box protein with seven tandem WD40 repeats. FBW7 is a key
substrate recognition subunit of the Skp1‑Cul1‑F‑box‑protein E3 ubiquitin ligase.
FBW7 targets for...
Non‑small cell lung cancer (NSCLC) constitutes the majority of all lung‑cancer
cases. Aquaporin 5 (AQP5) may be involved in NSCLC by promoting lung‑cancer initiation
and progression. The present study aimed to determine the role of AQP5 in migration
Biglycan (BGN), a key member of the small leucine‑rich proteoglycan family,
is an important component of the extracellular matrix. Clinical studies have demonstrated
that upregulation of BGN is associated with poor prognosis in patients with various
The underlying molecular mechanisms of pancreatic neuroendocrine tumor (pNET)
development have not yet been clearly identified. The present study revealed that
thrombospondin 2 (THBS2) was downregulated in pNET tissues and cells. Forced expression
Protein tyrosine phosphatase non‑receptor type 11 (PTPN11) encodes the tyrosine
phosphatase SHP‑2 that is overexpressed in gastric cancer (GC). In the present
study, the association of PTPN11 methylation levels with the incidence of GC and
its correlation with...
Spindle poisons are chemotherapeutic drugs used in the treatment of malignant
tumors; however, numerous patients develop resistance following chemotherapy.
The present study aimed to induce polyploidy in breast cancer cells using the
spindle poison nocodazole...
The identifcation of novel and accurate biomarkers is important to improve
the prognosis of patients with hepa‑tocellular carcinoma (HCC). C‑Type lectin
domain family 4 member M (CLEC4M) is involved in the progression of numerous cancer
types. However, the...
In the current Tumor-Node-Metastasis (TNM) classification system for renal
cell carcinoma (RCC), both perinephric fat invasion (PFI) and renal sinus fat
invasion (SFI) are classified at the T3a stage. However, their associated prognoses
A Disintegrin And Metalloprotease Domain 29 (ADAM29) and Family with sequence
similarity 135 member B (FAM135B) genes have been reported to be associated with
a carcinogenic risk of esophageal squamous cell carcinoma (ESCC). However, to
the best of our...
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