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Gemcitabine (GEM) is a typical chemotherapeutic drug used to treat pancreatic
cancer, but GEM resistance develops within weeks after chemotherapy. Hence, the
development of a new strategy to overcome drug resistance is urgent. 4‑Acetylantroquinonol B
Glioblastoma multiforme (GBM) is the most aggressive and lethal primary
glial brain tumor. It has an unfavorable prognosis and relatively ineffective
treatment protocols, with the median survival of patients being ~15 months. Tumor
resistance to treatment is...
Kinesin superfamily member 18B (KIF18B) has previously been reported to
be upregulated in breast cancer (BC) and is involved in BC tumorigenesis. Therefore,
the present study aimed to investigate the effects and underlying mechanisms of
KIF18B in BC....
Next‑generation sequencing (NGS) technology is used to evaluate hereditary
cancer risks of patients worldwide; however, information concerning the germline
multigene mutational spectrum among patients with breast cancer (BC) with consanguineous
marriage (CM) is...
Sphingosine 1‑phosphate (S1P) is a bioactive lipid involved in cancer progression
through its binding to S1P receptors (S1PRs). However, the association between
multiple myeloma (MM) and S1P is unclear. The current study aimed to investigate
The incidence of breast cancer (BC) ranks first among all kinds of female
malignancies. Its invasion, migration, apoptosis and resistance to chemotherapeutic
drugs are the focus of current research. Nuclear receptor binding protein 1 (NRBP1)
Thromboprophylaxis, as a preventive measure for cancer‑associated thrombosis
(CAT), may be beneficial for patients with active cancer and high‑risk for thrombosis.
The present post hoc analysis include a total of 407 patients enrolled in the
Greek Management of...
Targeting protein for Xenopus kinesin‑like protein 2 (TPX2) is upregulated
in various tumors, and several studies have demonstrated the role of TPX2 as a
prognostic marker in cancer. However, the function of TPX2 in neuroblastoma (NB)
has not been completely...
The aim of the present study was to evaluate the antitumor effects of 2,2',4'‑trihydroxychalcone
(7a) on the A549 human lung cancer cell line. A549 cells were treated with different
concentrations of 7a for different time periods. Cells without 7a were used as...
5‑Aminoimidazole‑4‑carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
(ATIC), a catalysing enzyme in the de novo purine biosynthetic
pathway, has been previously reported to be upregulated and to participate in
myeloma and hepatocellular...
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