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Head and neck cancer (HNC) comprises a heterogeneous variety of malignant
tumors, characterized by a relatively high tumor mutation burden. Previous data
have revealed that immune system dysfunction appears to serve a key role in the
development and progression...
Epidermal growth factor receptor (EGFR) upregulation is a typical characteristic
of head and neck squamous cell carcinoma (HNSCC). However, tyrosine kinase inhibitors
have not yet been able to achieve enough therapeutic benefit in clinical trials
Abstract. Patients with primary cancer receiving chemotherapy and/or radiotherapy
may develop therapy‑related acute leukemia (t‑AL). Therapy‑related acute myeloid
leukemia (t‑AML) accounts for the majority of these cases and is frequently associated
Lung adenocarcinoma (LUAD) has a high morbidity and mortality rate worldwide,
and its growth and metastasis require angiogenesis. The density of microvessels
in LUAD is positively correlated with metastasis and recurrence. Von Willebrand
factor (VWF) is a...
Artemether, a natural derivative of artemisinin, serves an antitumor role
in numerous types of cancer. However, the role and mechanism of action of artemether
in hepatocellular carcinoma (HCC) has remained elusive. The present study aimed
to investigate whether...
Circular RNAs (circRNAs/circs) have gained attention as a class of potential
biomarkers for the early detection of multiple cancers. However, the functions
and mechanisms of circRNAs in the oncogenesis of human colorectal cancer (CRC)
remain to be elucidated....
Despite the recent progression of treatments, the 5‑year survival rate of
patients with oral squamous cell carcinoma (OSCC) is still poor. One of the most
critical factors affecting prognosis is tumor metastasis. Developing novel molecular
targeted therapies by...
T‑cell immunoglobulin mucin‑3 (TIM‑3) expressed at the T‑cell surface acts
as an immune checkpoint when bound by its ligand galectin‑9. Blockade of immunosuppression
by the TIM3/galectin‑9 signalling pathway may offer novel therapeutic approaches
Insulin‑like growth factor binding protein 6 (IGFBP6) is a secreted protein
with a controversial role in human malignancies, being downregulated in most types
of human cancer, but upregulated in selected tumors. Ovarian cancer (OC) is a
Glioblastoma multiforme is the most frequent type of malignant brain tumor,
and is one of the most lethal and untreatable human tumors with a very poor survival
rate. Therefore, novel and effective strategies of treatment are required. Integrins
play a crucial...
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