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Colorectal cancer (CRC) harbors genetic alterations in a component of the
Wnt signaling pathway in ~90% of cases. In addition, the Wnt signaling pathway
has been previously suggested to serve a notable role in the pathophysiology of
CRC cells and...
Studies have shown that LIM domain kinase 1 (LIMK1) is upregulated in a
variety of tumors and may be a potential detection target. The present study analyzed
the expression difference of LIMK1 and its relationship with tumor clinicopathological
Innate immune sensor IFN‑induced protein 16 (IFI16) exhibits anti‑inflammatory
effects via IFNβ and IFN‑stimulated gene (ISG)15 induction in cancer cells. Epigallocatechin
gallate (EGCG) is a potent natural DNA methyltransferase inhibitor (DNMTi). Previous...
The aim of the present study was to explore the role and biological function
of bromodomain PHD finger transcription factor (BPTF) in T‑cell lymphoma. Reverse
transcription‑quantitative PCR (RT‑qPCR), western blotting, immunohistochemistry
While various molecular profiling methods have been described for the early
diagnosis and prognostic process of endometrial cancer, the most common gynaecological
cancer, the data obtained remain insufficient. The present study aimed to investigate
Neurite outgrowth inhibitor A (Nogo‑A), a member of the reticulon 4 family,
is an axon regeneration inhibitor that is negatively associated with the malignancy
of oligodendroglial tumors. It has been suggested that the Nogo‑A/Nogo Receptor
(NgR) pathway plays a...
Ganglioneuroblastoma (GNB) is a condition belonging to the neuroblastoma
family. It is a transitional tumor consisting of a mixture of mature ganglioneuromas
and malignant neuroblastomas. Its biological behavior is intermediate between
benign and malignant,...
The number of individuals diagnosed with colorectal cancer (CRC) has been
on an alarming upward trajectory over the past decade. In some countries, this
cancer represents one of the most frequently diagnosed types of neoplasia. Therefore,
it is an important...
The standard treatment for colorectal cancer has always been surgery and
chemotherapy, which may be used in combination to treat patients. Immune checkpoint
inhibitors have been a significant advancement in the standard treatment of metastatic,
Tumor‑infiltrating immune cells play an essential role in cancer progression
and may help supplement the Tumor, Node, Metastasis (TNM) classification for cancer
prognosis. Currently, there are numerous conflicting reports discussing the significance
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