ACS Chemical Neuroscience

Journal Article

Inhibition of PINK1-Mediated Mitophagy Contributes to Postoperative Cognitive Dysfunction through Activation of Caspase-3/GSDME-Dependent Pyroptosis

Wang, Wei; Zhao, Bo; Gao, Wenwei; Song, Wenqin; Hou, Jiabao;

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.2c00691 pmid:36946264

PTEN-induced kinase 1 (PINK1)-mediated mitophagy and caspase-1/gasdermin D canonical pyroptosis pathways have been implicated in the pathogenesis of postoperative cognitive dysfunction (POCD). However, gasdermin E (GSDME), another recently identified executioner of pyroptosis that can be...

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Journal Article

ALS-Linked A315T and A315E Mutations Enhance β‑Barrel Formation of the TDP-43307–319 Hexamer: A REST2 Simulation Study

Liu, Xianshi; Li, Xuhua; Qiao, Qin; Li, Fangying; Wei, Guanghong

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.3c00012 pmid:36888995

Pathogenic mutations of transactivation response element DNA-binding protein 43 (TDP-43) are closely linked with amyotrophic lateral sclerosis (ALS). It was recently reported that two ALS-linked familial mutants A315T and A315E of TDP-43307–319 peptides can self-assemble into oligomers including...

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Development of a Novel Electrochemiluminescence ELISA for Quantification of α‑Synuclein Phosphorylated at Ser129 in Biological Samples

Dutta, Suman; Hornung, Simon; Taha, Hash Brown; Biggs, Karl; Siddique, Ibrar;

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.2c00676 pmid:36920792

Synucleinopathies are a group of neurodegenerative diseases including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These diseases are characterized by the aggregation and deposition of α-synuclein (α-syn) in Lewy bodies (LBs) in PD and DLB or as...

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Journal Article

Anti-Strychnine Immunoconjugate Reduces the Effects of Strychnine-Induced Toxicity in Mice

Baehr, Carly; Kassick, Andrew J.; Vigliaturo, Jennifer; Luengas, Diego; Khaimraj, Aaron;

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.2c00797 pmid:36952479

Strychnine poisoning induces seizures that result in loss of control of airway muscles, leading to asphyxiation and subsequent death. Current treatment options are limited, requiring hands-on medical care and isolation to low-stimulus environments. Anticonvulsants and muscle relaxants have shown...

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Journal Article

Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors

Huang, Yuying; Chen, Hong; Chen, Shao-Rui; Pan, Hui-Lin

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.2c00780 pmid:36930958

Antidepressants, such as duloxetine and amitriptyline, are effective for treating patients with chronic neuropathic pain. Inhibiting norepinephrine and serotonin transporters at presynaptic terminals raises extracellular concentrations of norepinephrine. The α1- and α2-adrenergic receptor...

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Journal Article

Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways

Shi, Xiaoyi; Li, Meng; Huang, Qiming; Xie, Liuming; Huang, Zhibing

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.3c00104 pmid:36917811

Monacolin K (MK), a polyketo secondary metabolic compound of the mold genus Monascus, can promote the apoptosis of malignant cancer cells, possessing potential antitumor properties. However, its mechanism of action on gliomas remains unclear. Here, we explored and investigated the potential of...

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Journal Article

14-3-3ζ Participates in the Phase Separation of Phosphorylated and Glycated Tau and Modulates the Physiological and Pathological Functions of Tau

Liu, Yu-Qing; Liang, Chu-Qiao; Chen, Zhi-Wei; Hu, Jun; Hu, Jin-Jian;

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.3c00034 pmid:36939323

Tau plays a major role in Alzheimer’s disease (AD) and several other neurodegenerative diseases. Tau undergoing liquid–liquid phase separation (LLPS) performs specific physiological functions, induces pathological processes, and contributes to neurodegeneration. Regulating Tau phase separation...

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Journal Article

Small-Molecule Cdc25A Inhibitors Protect Neuronal Cells from Death Evoked by NGF Deprivation and 6‑Hydroxydopamine

Pramanik, Sumit Kumar; Sanphui, Priyankar; Das, Anoy Kumar; Banerji, Biswadip; Biswas, Subhas C.

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.2c00474 pmid:36942687

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative diseases that are presently incurable. There have been reports of aberrant activation of cell cycle pathways in neurodegenerative diseases. Previously, we have found that Cdc25A is activated in models...

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Journal Article

Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress

Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.;

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.2c00810 pmid:36881648

Increased ATP release and its extracellular catabolism through CD73 (ecto-5′-nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in different brain disorders. A2AR blockade blunts mood and memory dysfunction caused by repeated stress, but it is unknown if...

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Journal Article

Ethanol Metabolite, Acetate, Increases Excitability of the Central Nucleus of Amygdala Neurons through Activation of NMDA Receptors

Chapp, Andrew D.; Collins, Andréa R.; Driscoll, Kyle M.; Behnke, Jessica E.; Shan, Zhiying;

2023 ACS Chemical Neuroscience

doi:10.1021/acschemneuro.2c00784 pmid:36957993

The central nucleus of the amygdala (CeA) is a key brain region involved in emotional and stressor responses due to its many projections to autonomic regulatory centers. It is also a primary site of action from ethanol consumption. However, the influence of active metabolites of ethanol such as...

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