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Molecular and Clinical Oncology Volume 2 Issue 4

Subject Areas: Cancer Research
Publisher: Spandidos Publications - Spandidos Publications
ISSN: 2049-9450
SJR: 11

LitStream

Journal Article

Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors

Niu, Qi; Wang, Wei; Li, Qian; Li, Yong; Ruden, Douglas M.; Wang, Fenghua M.

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.275 pmid:24940482

Cisplatin (cis‑diammineplatinum dichloride (DDP)) resistance is a major limitation in the treatment of lung cancer. We previously demonstrated that DDP dissolved in 5% ethanol (5% ethanol‑DDP) injected intratumorally was able to eradicate DDP‑resistant lung tumors and prolong survival, as 5%...
LitStream

Journal Article

Successful treatment of rectal cancer with perineal invasion: Three case reports

Kitahara, Tomohiro; Uemura, Mamoru; Haraguchi, Naotsugu; Nishimura, Junichi; Shingai, Tatsushi; Hata, Taishi; Takemasa, Ichiro; Mizushima, Tsunekazu; Doki, Yuichiro; Mori, Masaki; Yamamoto, Hirofumi

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.282 pmid:24940483

Rectal cancer occasionally invades adjacent organs. however, rectal cancer with perineal invasion is uncommon and difficult to treat. Locally advanced colorectal cancer may be clinically treated with neoadjuvant therapy, followed by en bloc resection. Skin invasion may lead to tumor dissemination...
LitStream

Journal Article

Association between vascular endothelial growth factor gene polymorphisms and bladder cancer risk

Yang, Yanfeng; Zhang, Xuepei; Song, Dongkui; Wei, Jinxing

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.296 pmid:24940484

Vascular endothelial growth factor (VEGF) gene polymorphisms are associated with susceptibility to a number of cancers. The present case‑controlled study aimed to investigate the correlation between VEGF gene polymorphisms and the risk of bladder cancer. The effects of VEGF polymorphisms were...
LitStream

Journal Article

Association of serum hemoglobin A1c, C‑peptide and insulin‑like growth factor‑1 levels with the occurrence and development of lung cancer

Zhang, Meiyun; Li, Xiaofeng; Zhang, Xinyi; Yang, Yongyan; Feng, Zhiqing; Liu, Xiaoyan

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.289 pmid:24940485

The present study aimed to investigate the correlation of the of hemoglobin A1c (HbA1c), C‑peptide and insulin‑like growth factor‑1 (IGF‑1) levels with the development and progression of lung cancer. The serum HbA1c, C‑peptide and IGF‑1 levels were measured and compared between 80 lung cancer...
LitStream

Journal Article

Prognostic significance of the co‑overexpression of fibroblast growth factor receptors 1, 2 and 4 in gastric cancer

Murase, Hideaki; Inokuchi, Mikito; Takagi, Yoko; Kato, Keiji; Kojima, Kazuyuki; Sugihara, Kenichi

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.293 pmid:24940486

The overexpression of fibroblast growth factor receptor (FGFR) 2 is an established prognostic factor and treatment target in gastric cancer. However, the roles of other FGFRs have not been fully elucidated. In this study, we investigated the correlations of the expression of FGFR1‑4 with...
LitStream

Journal Article

Comparison of outcomes between squamous cell carcinoma and adenocarcinoma in patients with surgically treated stage I‑II cervical cancer

Yamauchi, Makoto; Fukuda, Takeshi; Wada, Takuma; Kawanishi, Masaru; Imai, Kenji; Hashiguchi, Yasunori; Ichimura, Tomoyuki; Yasui, Tomoyo; Sumi, Toshiyuki

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.295 pmid:24940487

To improve our understanding of cervical adenocarcinoma (AD) and evaluate the clinical and pathological variables affecting its prognosis, we retrospectively reviewed the medical records of 455 patients with cervical cancer (International Federation of Gynecology and Obstetrics stage I/II; 91...
LitStream

Journal Article

Correlation between positron emission tomography findings and glucose transporter 1, 3 and L‑type amino acid transporter 1 mRNA expression in primary central nervous system lymphomas

Takahashi, Yoshinobu; Akahane, Toshiaki; Yamamoto, Daisuke; Nakamura, Hideo; Sawa, Hiroki; Nitta, Kazumi; Ide, Wataru; Hashimoto, Ikuo; Kamada, Hajime

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.287 pmid:24940488

Primary central nervous system lymphoma (PCNSL) is an aggressive form of non‑Hodgkin lymphoma with a poor prognosis. (18F) 2‑fluoro‑2‑deoxy‑d‑glucose (FDG) and l‑(methyl‑11C)‑methionine (MET) are the most widely used tracers in oncological positron emission tomography studies for PCNSL and...
LitStream

Journal Article

Laparoscopic radical gastrectomy versus traditional open surgery in elderly patients with gastric cancer: Benefits and complications

Li, Hongtao; Han, Xiaopeng; Su, Lin; Zhu, Wankun; Xu, Wei; Li, Kun; Zhao, Qingchuan; Yang, Hua; Liu, Hongbin

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.283 pmid:24940489

This study was conducted to compare the therapeutic effect and complications of laparoscopic radical gastrectomy (LRG) with those of traditional open surgery in elderly patients with gastric cancer (GC). We conducted a retrospective comparison of therapeutic efficacy and complications between...
LitStream

Journal Article

Misjudgement of gefitinib efficacy in patients with central non-small‑cell lung cancer due to obstructive atelectasis caused by stereotactic radiotherapy

Yang, Xueqin; Xiong, Yanli; Huang, Huan; Peng, Bo; Zhou, Zejun; Xu, Mingfang; Yang, Yi; Wang, Dong

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.284 pmid:24940490

Stereotactic body radiation therapy (SBRT) has been reported to be safe and effective for the treatment of central lung cancer, with mostly tolerable early complications. In this study, we report the development of severe obstructive atelectasis as a late complication in two patients with central...
LitStream

Journal Article

Overexpression of G protein‑coupled receptor 87 correlates with poorer tumor differentiation and higher tumor proliferation in non‑small‑cell lung cancer

Nii, Kazuhito; Tokunaga, Yoshimasa; Liu, Dage; Zhang, Xia; Nakano, Jun; Ishikawa, Shinya; Kakehi, Yoshiyuki; Haba, Reiji; Yokomise, Hiroyasu

2014 Molecular and Clinical Oncology

doi:10.3892/mco.2014.292 pmid:24940491

G protein‑coupled receptor 87 (GPR87) is a newly deorphanized member of the transmembrane G protein‑coupled receptor family. Recently, GPR87 was suggested to contribute to the viability of human tumor cells and overexpression of GPR87 mRNA was detected in a number of malignant tumors, including...

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