Cancers

Journal Article

HER2 Intratumoral Heterogeneity in Breast Cancer, an Evolving Concept

Hou, Yanjun; Nitta, Hiroaki; Li, Zaibo

2023 Cancers

Amplification and/or overexpression of human epidermal growth factor receptor 2 (HER2) in breast cancer is associated with an adverse prognosis. The introduction of anti-HER2 targeted therapy has dramatically improved the clinical outcomes of patients with HER2-positive breast cancer....

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Journal Article

Sex- and Co-Mutation-Dependent Prognosis in Patients with SMARCA4-Mutated Malignancies

Pan, Minggui; Jiang, Chen; Zhang, Zheyang; Achacoso, Ninah; Solorzano-Pinto, Aleyda V.;

2023 Cancers

doi:10.3390/cancers15102665

Background: Whether sex and co-mutations impact prognosis of patients with SMARCA4-mutated (mutSMARCA4) malignancies is not clear. Methods: This cohort included patients from Northern California Kaiser Permanente with next-generation sequencing (NGS) performed from August 2020 to October 2022. We...

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Journal Article

Evaluation of Semen Self-Sampling Yield Predictors and CTC Isolation by Multi-Color Flow Cytometry for Liquid Biopsy of Localized Prostate Cancer

Saitta, Cesare; De Simone, Ilaria; Fasulo, Vittorio; Corbetta, Marinella; Duga, Stefano;

2023 Cancers

doi:10.3390/cancers15102666

Liquid biopsy (LB) for prostate cancer (PCa) detection could represent an alternative to biopsy. Seminal fluid (SF) is a source of PCa-specific biomarkers, as 40% of ejaculate derives from the prostate. We tested the feasibility of an SF-based LB by evaluating the yield of semen self-sampling in...

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Journal Article

The Current Treatment Trends and Survival Patterns in Melanoma Patients with Positive Sentinel Lymph Node Biopsy (SLNB): A Multicenter Nationwide Study

Ziętek, Marcin; Teterycz, Paweł; Wierzbicki, Jędrzej; Jankowski, Michał; Las-Jankowska, Manuela;

2023 Cancers

doi:10.3390/cancers15102667

Background: In melanoma treatment, an approach following positive sentinel lymph node biopsy (SLNB) has been recently deescalated from completion lymph node dissection (CLND) to active surveillance based on phase III trials data. In this study, we aim to evaluate treatment strategies in...

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Journal Article

Evaluation of the Oesophagogastric Cancer-Associated Microbiome: A Systematic Review and Quality Assessment

Vadhwana, Bhamini; Tarazi, Munir; Boshier, Piers R.; Hanna, George B.

2023 Cancers

doi:10.3390/cancers15102668

Objective. Oesophagogastric cancer is the fifth most common cancer worldwide, with poor survival outcomes. The role of bacteria in the pathogenesis of oesophagogastric cancer remains poorly understood. Design. A systematic search identified studies assessing the oesophagogastric cancer...

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Journal Article

An Image-Based Identification of Aggressive Breast Cancer Circulating Tumor Cell Subtypes

Kamal, Mohamed; Wang, Yiru Jess; Plummer, Sarai; Dickerson, Amber; Yu, Min

2023 Cancers

doi:10.3390/cancers15102669

Using previously established CTC lines from breast cancer patients, we identified different morphometric subgroups of CTCs with one of them having the highest tumorigenic potential in vivo despite the slowest cell proliferation in vitro. This subgroup represents 32% of all cells and contains...

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Journal Article

Re-Evaluating the Role of PTHrP in Breast Cancer

Kane, Jeremy F.; Johnson, Rachelle W.

2023 Cancers

doi:10.3390/cancers15102670

Parathyroid-hormone-related protein (PTHrP) is a protein with a long history of association with bone metastatic cancers. The paracrine signaling of PTHrP through the parathyroid hormone receptor (PTHR1) facilitates tumor-induced bone destruction, and PTHrP is known as the primary driver of...

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Journal Article

Advances in Lung Cancer Therapy

Galetta, Domenico

2023 Cancers

doi:10.3390/cancers15102671

Lung cancer, including both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), remains one of the most aggressive types of cancer, and the prognosis for individuals diagnosed with this neoplasm has, for the most part, been insufficient [...]

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Journal Article

RadWise: A Rank-Based Hybrid Feature Weighting and Selection Method for Proteomic Categorization of Chemoirradiation in Patients with Glioblastoma

Tasci, Erdal; Jagasia, Sarisha; Zhuge, Ying; Sproull, Mary; Cooley Zgela, Theresa;

2023 Cancers

doi:10.3390/cancers15102672

Glioblastomas (GBM) are rapidly growing, aggressive, nearly uniformly fatal, and the most common primary type of brain cancer. They exhibit significant heterogeneity and resistance to treatment, limiting the ability to analyze dynamic biological behavior that drives response and resistance, which...

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Journal Article

Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach

Amin, Aamir; Morello, Marzia; Petrara, Maria Raffaella; Rizzo, Beatrice; Argenton, Francesco;

2023 Cancers

doi:10.3390/cancers15102673

Telomerase reverse transcriptase (TERT), the catalytic component of telomerase, may also contribute to carcinogenesis via telomere-length independent mechanisms. Our previous in vitro and in vivo studies demonstrated that short-term telomerase inhibition by BIBR1532 impairs cell proliferation...

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