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Dissolution testing of drug formulations was introduced in the 1960s and accepted by health regulatory authorities in the 1970s. Since then, the importance of dissolution has grown rapidly as have the number of tests and demands in quality-control laboratories. Recent research works lead to the...
Automation has long been a resource for high-throughput screening at Bristol-Myers Squibb. However, with growing deck sizes and decreasing time lines, a new generation of more robust, supportable automated systems was necessary for accomplishing high-throughput screening goals. Implementation of...
In the development of test methods for solid dosage forms, manual test procedures for assay and content uniformity often precede the development of automated test procedures. Since the mode of extraction for automated test methods is often slightly different from that of the manual test method,...
The development of a dedicated automated sequential-injection analysis apparatus for anodic stripping voltammetry (ASV) and adsorptive stripping voltammetry (AdSV) is reported. The instrument comprised a peristaltic pump, a multiposition selector valve and a home-made potentiostat and used a...
A commercially available fibrinogen standard calibrated by a World Health Organization (WHO) reference material is widely used in Japan, and most clinical laboratories use the Clauss method for plasma fibrinogen measurement. However, a current issue in fibrinogen measurement is poor...
The modelling of the parameters that influence the continuous evaporation of an alcoholic extract was considered using Doehlert matrices. The work was performed with a wiped falling film evaporator that allowed us to study the influence of the pressure, temperature, feed flow and dry matter of...
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