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ACS Combinatorial Science

Subject Areas: Chemistry (miscellaneous)
Publisher: American Chemical Society - American Chemical Society
ISSN: 2156-8944
SJR: 84

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Journal Article

Issue Publication Information

2020 ACS Combinatorial Science

doi:10.1021/cov022i012_1436415
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Journal Article

Issue Editorial Masthead

2020 ACS Combinatorial Science

doi:10.1021/cov022i012_1436416
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Journal Article

ACS Combinatorial Science: January, 1999–December, 2020

Finn, M. G.

2020 ACS Combinatorial Science

doi:10.1021/acscombsci.0c00181 pmid:33307697
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Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

Ashrafizadeh, Milad; Zarrabi, Ali; Hushmandi, Kiavash; Hashemi, Farid; Rahmani Moghadam, Ebrahim; Raei, Mehdi; Kalantari, Mahshad; Tavakol, Shima; Mohammadinejad, Reza; Najafi, Masoud; Tay, Franklin R.; Makvandi, Pooyan

2020 ACS Combinatorial Science

doi:10.1021/acscombsci.0c00099 pmid:33095554

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because of the outstanding therapeutic activity and multitargeting capability of these compounds. However, poor solubility and...
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Sorting Technology for Circulating Tumor Cells Based on Microfluidics

Hu, Dayu; Liu, He; Tian, Ye; Li, Zhi; Cui, Xiaoyu

2020 ACS Combinatorial Science

doi:10.1021/acscombsci.0c00157 pmid:33052651

Circulating tumor cells (CTCs) carry reliable clinical information for the diagnosis and treatment of cancer that is a malignant disease with a high mortality rate. However, the amount of CTCs in the blood is quite low. To obtain credible clinical information, an efficient method of extracting...
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Expanding the Chemical Diversity of Genetically Encoded Libraries

Iskandar, Sabrina E.; Haberman, Victoria A.; Bowers, Albert A.

2020 ACS Combinatorial Science

doi:10.1021/acscombsci.0c00179 pmid:33167616

The power of ribosomes has increasingly been harnessed for the synthesis and selection of molecular libraries. Technologies, such as phage display, yeast display, and mRNA display, effectively couple genotype to phenotype for the molecular evolution of high affinity epitopes for many therapeutic...
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Development of Measurement Tools for High-Throughput Experiments of Synchrotron Radiation XRD and XAFS on Powder Libraries

Fujimoto, Kenjiro; Aimi, Akihisa; Maruyama, Shingo

2020 ACS Combinatorial Science

doi:10.1021/acscombsci.0c00174 pmid:33095010

We propose to minimize the sampling time for high-throughput measurements of powder X-ray diffraction (XRD) and X-ray absorption fine structure (XAFS) in synchrotron radiation. The conventional synchrotron radiation powder X-ray diffraction method requires filling of a capillary tube, but a...
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Journal Article

Use of Target-Displaying Magnetized Yeast in Screening mRNA-Display Peptide Libraries to Identify Ligands

Bacon, Kaitlyn; Bowen, John; Reese, Hannah; Rao, Balaji M.; Menegatti, Stefano

2020 ACS Combinatorial Science

doi:10.1021/acscombsci.0c00171 pmid:33089990

This work presents the first use of yeast-displayed protein targets for screening mRNA-display libraries of cyclic and linear peptides. The WW domains of Yes-Associated Protein 1 (WW-YAP) and mitochondrial import receptor subunit TOM22 were adopted as protein targets. Yeast cells displaying...
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Journal Article

Detection of Thiol Functionality and Disulfide Bond Formation by Polyoxometalate

Konno, Hiroyuki; Yasumiishi, Haruto; Aoki, Reika; Nitanai, Ikumi; Yano, Shigekazu

2020 ACS Combinatorial Science

doi:10.1021/acscombsci.0c00176 pmid:33030888

The detection of thiol functionality and intramolecular disulfide bond formation of peptides using the α-Keggin type polyoxometalate molybdenum–oxygen cluster (H3PMo12O40·nH2O) is described. Our method entails the addition of this polyoxometalate to solutions of thiol, whereupon the color of the...
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Journal Article

High Throughput Synthesis and Screening of Oxygen Reduction Catalysts in the MTiO3 (M = Ca, Sr, Ba) Perovskite Phase Diagram

Groves, Alexandra R.; Ashton, Thomas E.; Darr, Jawwad A.

2020 ACS Combinatorial Science

doi:10.1021/acscombsci.0c00094 pmid:33151687

A library of 66 perovskite Ba x Sr y Ca z TiO3 (x + y + z = 1) samples (ca. three grams per sample) was made in ca. 14 h using a high-throughput continuous hydrothermal flow synthesis system. The as-synthesized samples were collected from the outlet of the process and then cleaned and...

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