1 - 10 of 44 articles
Survival benefit and a manageable safety profile were observed with G47Δ in patients with glioblastoma.
Germinal center B (GCB) cells provide a niche to support the development of angioimmunoblastic T-cell lymphoma.
An organoid-based, 3D imaging–transcriptomic platform was developed to investigate immunotherapy modes of action.
Redundant and antiquated procedures, inefficient data reporting, staffing shortages, and declining clinical trial participation have created a clinical research crisis that's slowing clinical research and drug approvals, experts say. But they offer possible solutions to these problems.
Although the treatment landscape for small cell lung cancer has hardly changed in decades, new possibilities are emerging. Long-term data from KEYNOTE-604 support incorporating immune checkpoint inhibition up front, as this provides durable benefit. A bispecific T-cell engager and other...
Cancer cell–derived Col1 homotrimers regulate the PDAC microbiome and block T-cell infiltration.
A gorilla adenovirus vaccine targeting tumor neoepitopes enhances the activity of anti–PD-1 therapy.
Multicellular dynamics, including neoadjuvant treatment–associated changes, were uncovered in PDAC.
COX-2+ lung fibroblasts reprogram myeloid cells to be immunosuppressive and support lung metastasis.
Addition of genetic risk score to prediction models improves obesity risk prediction in adult survivors of childhood cancer.
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