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Cancer Discovery

Subject Areas: Oncology
Publisher: American Association for Cancer Research - American Association of Cancer Research
ISSN: 2159-8274
SJR: 187

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Journal Article

The Oncolytic Virus G47Δ Shows Efficacy and Safety in Glioblastoma

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-rw2022-139 pmid:35929750

Survival benefit and a manageable safety profile were observed with G47Δ in patients with glioblastoma.
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Journal Article

Clonal GCB Cells Support Angioimmunoblastic T-cell Lymphoma Tumorigenesis

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-rw2022-148 pmid:35984242

Germinal center B (GCB) cells provide a niche to support the development of angioimmunoblastic T-cell lymphoma.
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Journal Article

The BEHAV3D Platform Demonstrates Cellular Immunotherapy Modes of Action

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-rw2022-144 pmid:35960018

An organoid-based, 3D imaging–transcriptomic platform was developed to investigate immunotherapy modes of action.
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Journal Article

Numerous Challenges Create Clinical Research Crisis

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-nd2022-0014 pmid:36005766

Redundant and antiquated procedures, inefficient data reporting, staffing shortages, and declining clinical trial participation have created a clinical research crisis that's slowing clinical research and drug approvals, experts say. But they offer possible solutions to these problems.
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Journal Article

SCLC's Treatment Arsenal Improving

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-nd2022-0013 pmid:35980130

Although the treatment landscape for small cell lung cancer has hardly changed in decades, new possibilities are emerging. Long-term data from KEYNOTE-604 support incorporating immune checkpoint inhibition up front, as this provides durable benefit. A bispecific T-cell engager and other...
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Journal Article

Collagen I Homotrimers Promote PDAC Growth and Impact Immunity

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-rw2022-138 pmid:35929752

Cancer cell–derived Col1 homotrimers regulate the PDAC microbiome and block T-cell infiltration.
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Journal Article

Adenoviral-Based Cancer Vaccines Promote Anti–PD-1 Treatment Efficacy

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-rw2022-152 pmid:36018032

A gorilla adenovirus vaccine targeting tumor neoepitopes enhances the activity of anti–PD-1 therapy.
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Journal Article

Multicellular Dynamics Associated with Clinical Outcome Were Discovered in PDAC

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-rw2022-143 pmid:35960023

Multicellular dynamics, including neoadjuvant treatment–associated changes, were uncovered in PDAC.
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Journal Article

Lung Fibroblasts Support Metastasis through Immune Microenvironment Remodeling

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-rw2022-149 pmid:35984238

COX-2+ lung fibroblasts reprogram myeloid cells to be immunosuppressive and support lung metastasis.
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Journal Article

Genetic Risk Score Improves Prediction of Severe Obesity after Childhood Cancer

2022 Cancer Discovery

doi:10.1158/2159-8290.cd-rw2022-141 pmid:35929748

Addition of genetic risk score to prediction models improves obesity risk prediction in adult survivors of childhood cancer.

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