ACS Macro Letters

Journal Article

pH-Responsive Mucus-Penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue

Zhang, Yating; Li, Shenghui; Loch, Kirsten; Duncan, Gregg A.; Kaler, Logan;

2023 ACS Macro Letters

doi:10.1021/acsmacrolett.2c00639 pmid:36951898

Low mucus penetration ability and cellular uptake seriously limit the effectiveness of local vaginal drug administration because of the rapid foreign particulate and pathogen removal property of the mucus layer. Our previous work proved that nanoparticles with a highly dense polyethylene glycol...

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Journal Article

Thermal Transformation of Polyacrylonitrile Accelerated by the Formation of Ultrathin Nanosheets in a Metal–Organic Framework

Zhang, Xiyuan; Kitao, Takashi; Nishijima, Ami; Uemura, Takashi

2023 ACS Macro Letters

doi:10.1021/acsmacrolett.3c00072 pmid:36916794

In this study, polyacrylonitrile (PAN) nanosheets with unimolecular thickness were successfully synthesized by cross-linking polymerization in the 2D nanospaces of a metal–organic framework. In contrast to 1D and 3D analogues, crystallization could be inhibited by the topological constraint of...

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Journal Article

Validation of an Accurate and Expedient Initial Rates Method for Characterizing Mechanophore Reactivity

McFadden, Molly E.; Overholts, Anna C.; Osler, Skylar K.; Robb, Maxwell J.

2023 ACS Macro Letters

doi:10.1021/acsmacrolett.3c00054 pmid:36944217

Understanding structure–mechanochemical reactivity relationships is important for informing the rational design of new stimuli-responsive polymers. To this end, establishing accurate reaction kinetics for mechanophore activation is a key objective. Here, we validate an initial rates method that...

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Journal Article

Increasing the Mechanical Stability of Polymer–Gold Interfacial Connection: A Parallel Covalent Strategy

Ma, Ziwen; Zhang, Honglin; Song, Yu; Mei, Qiuping; Shi, Pengju;

2023 ACS Macro Letters

doi:10.1021/acsmacrolett.3c00058 pmid:36924462

Thiol–gold (S–Au) chemistry has been widely used in coating and functionalizing gold surfaces because it is robust and highly efficient. However, recent studies have shown that the S–Au-based self-assembled monolayers can lead to significant instability under external mechanical loading (e.g.,...

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Journal Article

Simultaneous Polymerization Acceleration and Mechanical Enhancement for Printing a Biomimetic PEDOT Adhesive by Coordinative and Orthogonal Ruthenium Photochemistry

Xiao, Wenqing; Liu, Jupen; Lu, Zhe; Zhang, Ping; Wei, Hongqiu;

2023 ACS Macro Letters

doi:10.1021/acsmacrolett.2c00759 pmid:36930947

Conductive hydrogels are promising material candidates in fields ranging from flexible sensors and electronic skin applications to personalized medical monitoring. However, developing intrinsically conductive polymer hydrogels (ICPHs) with high mechanical properties and excellent printability is...

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Journal Article

Gradient Copolymer Synthesis through Self-Assembly

Scheutz, Georg M.; Bowman, Jared I.; Mondal, Swagata; Rho, Julia Y.; Garrison, John B.;

2023 ACS Macro Letters

doi:10.1021/acsmacrolett.3c00148 pmid:36952321

Polymerization-induced self-assembly (PISA) is typically performed to produce polymer nanoparticles featuring specific assembly morphologies. Herein, we demonstrate the use of PISA as a synthetic tool to direct gradient copolymer synthesis. Specifically, we leverage hydrophobicity-induced...

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Journal Article

Brush Polymer Coatings with Hydrophilic Main-Chains for Improving Surface Antibacterial Properties

Chu, Xiaotang; Wu, Fan; Liu, Zhiwei; Yin, Lichen; Luan, Shifang;

2023 ACS Macro Letters

doi:10.1021/acsmacrolett.2c00761

Polymer coatings with improved surface antibacterial properties are of great importance for the application and development of implantable medical devices. Herein, we report the design, preparation, and antibacterial properties of a series of brush polymers (Dex-KEs) with hydrophilic dextran...

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