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Each year, thousands of new mouse models are generated around the world to further biomedical research. Unfortunately, the cost of maintaining mouse colonies makes it uneconomical to keep strains on the shelf that are not part of active research programs. Ideally, these retired strains should be...
The skin and its adnexa (hair and nails) comprise one of the easiest organ systems to evaluate, as they are the most accessible. However, mice are small and have lots of very fine hairs of multiple types. Thus, while major abnormalities are obvious, subtle abnormalities or the basis for these...
Parkinson's disease is a neurodegenerative disorder characterized by the loss of neurons in specific regions of the nervous system, notably in the substantia nigra pars compacta and, in most cases, by the deposition of intraneuronal inclusions named Lewy bodies. These pathological alterations...
This unit describes a novel method for direct venous injection into mice that offers potentially significant advantages over commonly used mouse vein injection techniques. This is achieved via percutaneous needle placement into the mouse jugular vein under real‐time B‐mode ultrasound (US)...
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