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The simple protocol described in this article aims to provide all required information, as a comprehensive, easy‐to‐follow step‐by‐step method, to ensure the generation of the expected genome‐edited mice. Here, we provide protocols for the preparation of CRISPR‐Cas9 reagents for microinjection...
Generating large‐fragment knock‐ins, such as reporters, conditional alleles, or humanized alleles, directly in mouse embryos is still a challenging feat. We have developed 2C‐HR‐CRISPR, a technology that allows highly efficient (10‐50%) and rapid (generating founders in 2 months) targeting of...
Current preclinical cognitive assessments are highly time intensive, with lengthy assessment procedures. In this regard, a single‐day assay that focuses just on assessing learning behavior in a time‐effective and relatable manner would be of value. This article describes the box maze as a...
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