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Understanding RNA expression in space and time is a key initial step in dissecting gene function. The ability to visualize gene expression in whole‐tissue or whole‐specimen preparations, called in situ hybridization (ISH), was first developed 50 years ago. Two decades later, these protocols were...
Experiments that visualize gene expression in intact tissues or organisms are fundamental to studies of gene function. These experiments, called in situ hybridization, require the production of a riboprobe, which is a labeled antisense RNA corresponding to a particular gene. The most commonly...
In situ hybridization is a powerful technique that allows the visualization of specific RNA species in biological samples in exquisite detail. It has been particularly well explored in the field of developmental genetics. The spatial and temporal patterns of RNA expression provide us with...
The light (or optical) microscope is the icon of science. The aphorism “seeing is believing” is often quoted in scientific papers involving microscopy. Unlike many scientific instruments, the light microscope will deliver an image however badly it is set up. Fluorescence microscopy is a widely...
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