Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

DeepDyve requires Javascript to function. Please enable Javascript on your browser to continue.

npj Parkinson s Disease

Subject Areas: Neurology (clinical)
Publisher: Nature Publishing Group UK - Springer Journals
SJR: 31

FREE

Journal Article

A nationwide cohort study on diabetes severity and risk of Parkinson disease

Han, Kyungdo; Kim, Bongsung; Lee, Seung Hwan; Kim, Mee Kyoung

2023 npj Parkinson's Disease

doi:10.1038/s41531-023-00462-8 pmid:36707543

There is growing evidence that patients with type 2 diabetes mellitus (DM) have an increased risk of developing Parkinson’s disease (PD) and share similar dysregulated pathways. We aimed to determine whether the risk of PD increases as diabetes progresses among patients with type 2 DM. Using a...
FREE

Journal Article

Glycolysis-enhancing α1-adrenergic antagonists modify cognitive symptoms related to Parkinson’s disease

Weber, Matthew A.; Sivakumar, Kartik; Tabakovic, Ervina E.; Oya, Mayu; Aldridge, Georgina M.; Zhang, Qiang; Simmering, Jacob E.; Narayanan, Nandakumar S.

2023 npj Parkinson s Disease

doi:10.1038/s41531-023-00477-1 pmid:36864060

Terazosin is an α1-adrenergic receptor antagonist that enhances glycolysis and increases cellular ATP by binding to the enzyme phosphoglycerate kinase 1 (PGK1). Recent work has shown that terazosin is protective against motor dysfunction in rodent models of Parkinson’s disease (PD) and is...
FREE

Journal Article

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients

Lofredi, Roxanne; Okudzhava, Liana; Irmen, Friederike; Brücke, Christof; Huebl, Julius; Krauss, Joachim K.; Schneider, Gerd-Helge; Faust, Katharina; Neumann, Wolf-Julian; Kühn, Andrea A.

2023 npj Parkinson's Disease

doi:10.1038/s41531-022-00443-3 pmid:36611027

Pathologically increased beta power has been described as a biomarker for Parkinson’s disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we investigate the association between subthalamic beta dynamics and motor impairment in a cohort of 106 Parkinson’s...
FREE

Journal Article

A systematic review and meta-analysis of inflammatory biomarkers in Parkinson’s disease

Qu, Yi; Li, Jiangting; Qin, Qixiong; Wang, Danlei; Zhao, Jingwei; An, Ke; Mao, Zhijuan; Min, Zhe; Xiong, Yongjie; Li, Jingyi; Xue, Zheng

2023 npj Parkinson s Disease

doi:10.1038/s41531-023-00449-5 pmid:36739284

Neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD), but controversies persist. Studies reporting concentrations of blood or cerebrospinal fluid (CSF) markers for patients with PD and controls were included and extracted. Pooled Hedges’g was adopted to...
FREE

Journal Article

Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder

Baldelli, Luca; Pirazzini, Chiara; Sambati, Luisa; Ravaioli, Francesco; Gentilini, Davide; Calandra-Buonaura, Giovanna; Guaraldi, Pietro; Franceschi, Claudio; Cortelli, Pietro; Garagnani, Paolo; Bacalini, Maria Giulia; Provini, Federica

2023 npj Parkinson s Disease

doi:10.1038/s41531-023-00492-2 pmid:36997543

Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured...
FREE

Journal Article

Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1

Jacquemyn, Julie; Kuenen, Sabine; Swerts, Jef; Pavie, Benjamin; Vijayan, Vinoy; Kilic, Ayse; Chabot, Dries; Wang, Yu-Chun; Schoovaerts, Nils; Corthout, Nikky; Verstreken, Patrik

2023 npj Parkinson s Disease

doi:10.1038/s41531-023-00459-3 pmid:36739293

Recent evidence links dysfunctional lipid metabolism to the pathogenesis of Parkinson’s disease, but the mechanisms are not resolved. Here, we generated a new Drosophila knock-in model of DNAJC6/Auxilin and find that the pathogenic mutation causes synaptic dysfunction, neurological defects and...
FREE

Journal Article

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

Ng, Xin Yi; Wu, Yumei; Lin, Youneng; Yaqoob, Sidra Mohamed; Greene, Lois E.; De Camilli, Pietro; Cao, Mian

2023 npj Parkinson s Disease

doi:10.1038/s41531-023-00465-5 pmid:36792618

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and auxilin, have been implicated in atypical Parkinsonism. SJ1...
FREE

Journal Article

Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice

Skiteva, Olga; Yao, Ning; Mantas, Ioannis; Zhang, Xiaoqun; Perlmann, Thomas; Svenningsson, Per; Chergui, Karima

2023 npj Parkinson s Disease

doi:10.1038/s41531-023-00500-5 pmid:37029193

In Parkinson’s disease (PD), axons of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) degenerate before their cell bodies. Calcium influx during pacemaker firing might contribute to neuronal loss, but it is not known if dysfunctions of voltage-gated calcium channels (VGCCs)...
FREE

Journal Article

A proteogenomic view of Parkinson’s disease causality and heterogeneity

Kaiser, Sergio; Zhang, Luqing; Mollenhauer, Brit; Jacob, Jaison; Longerich, Simonne; Del-Aguila, Jorge; Marcus, Jacob; Raghavan, Neha; Stone, David; Fagboyegun, Olumide; Galasko, Douglas; Dakna, Mohammed; Bilican, Bilada; Dovlatyan, Mary; Kostikova, Anna; Li, Jingyao; Peterson, Brant; Rotte, Michael; Sanz, Vinicius; Foroud, Tatiana; Hutten, Samantha J.; Frasier, Mark; Iwaki, Hirotaka; Singleton, Andrew; Marek, Ken; Crawford, Karen; Elwood, Fiona; Messa, Mirko; Serrano-Fernandez, Pablo

2023 npj Parkinson s Disease

doi:10.1038/s41531-023-00461-9 pmid:36774388

The pathogenesis and clinical heterogeneity of Parkinson’s disease (PD) have been evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput proteomic analysis of cerebrospinal fluid (CSF) opened new opportunities for scrutinizing this heterogeneity. To date, this is...
FREE

Journal Article

Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson’s disease

Zhang, Xi; Xu, Sutong; Hu, Yong; Liu, Qiulu; Liu, Chenming; Chai, Huazhen; Luo, Yuping; Jin, Lingjing; Li, Siguang

2023 npj Parkinson s Disease

doi:10.1038/s41531-023-00453-9 pmid:36720890

Exercise has been proposed as an effective non-pharmacological management for Parkinson’s disease (PD) patients. Irisin, a recently identified myokine, is increased by exercise and plays pivotal roles in energy metabolism. However, it remains unknown whether irisin has any protective effects on...

results per page

Prev
1
2
3
4
5
6
Next