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ACS Infectious Diseases

Subject Areas: Infectious Diseases
Publisher: American Chemical Society - American Chemical Society
ISSN: 2373-8227
SJR: 46

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Journal Article

Alanyl-Glutamine (Ala-Gln) Ameliorates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by Regulating the Gut Microbiota, PI3K-Akt/NF-κB/STAT3 Signaling, and Associated Pulmonary Injury

Liu, Jing; Zong, Chengguo; Yu, Xin; Ding, Yan; Chang, Bing; Wang, Ruoyu; Sang, Lixuan

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.3c00014 pmid:36917734

The aim of this study was to investigate the protective effect of alanyl-glutamine (Ala-Gln) on acute colitis complicated by pulmonary injury induced by dextran sulfate sodium (DSS) in C57BL/6 mice. The results showed that Ala-Gln intervention alleviated weight loss, the disease activity index...
Available

Journal Article

Design, Synthesis, and Evaluation of Carbonate-Linked Halogenated Phenazine-Quinone Prodrugs with Improved Water-Solubility and Potent Antibacterial Profiles

Xiao, Tao; Liu, Ke; Gao, Qiwen; Chen, Manyun; Kim, Young S.; Jin, Shouguang; Ding, Yousong; ,

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.2c00558 pmid:36867688

Pathogenic bacteria have devastating impacts on human health as a result of acquired antibiotic resistance and innate tolerance. Every class of our current antibiotic arsenal was initially discovered as growth-inhibiting agents that target actively replicating (individual, free-floating)...
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Journal Article

Aprosamine Derivatives Active against Multidrug-Resistant Gram-Negative Bacteria

Otsuka, Yasunari; Umemura, Eijiro; Takamiya, Yukimi; Ishibashi, Teruhisa; Hayashi, Chigusa; Yamada, Keiko; Igarashi, Masayuki; Shibasaki, Masakatsu; Takahashi, Yoshiaki

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.2c00557 pmid:36893496

Novel aprosamine derivatives were synthesized for the development of aminoglycoside antibiotics active against multidrug-resistant Gram-negative bacteria. The synthesis of aprosamine derivatives involved glycosylation at the C-8′ position and subsequent modification (epimerization and...
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Journal Article

Evaluation of Antiviral Activity of Gemcitabine Derivatives against Influenza Virus and Severe Acute Respiratory Syndrome Coronavirus 2

Cha, Hyeon-Min; Kim, Uk-Il; Ahn, Soo Bin; Lee, Myoung Kyu; Lee, Haemi; Bang, Hyungtae; Jang, Yejin; Kim, Seong Soon; Bae, Myung Ae; Kim, Kyungjin; Kim, Meehyein

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.3c00034

Gemcitabine is a nucleoside analogue of deoxycytidine and has been reported to be a broad-spectrum antiviral agent against both DNA and RNA viruses. Screening of a nucleos(t)ide analogue-focused library identified gemcitabine and its derivatives (compounds 1, 2a, and 3a) blocking influenza virus...
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Journal Article

Chimeric Tobramycin-Based Adjuvant TOB-TOB-CIP Potentiates Fluoroquinolone and β‑Lactam Antibiotics against Multidrug-Resistant Pseudomonas aeruginosa

Dhiman, Shiv; Ramirez, Danyel; Li, Yanqi; Kumar, Ayush; Arthur, Gilbert; Schweizer, Frank

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.2c00549 pmid:36917096

According to the World Health Organization, antibiotic resistance is a global health threat. Of particular importance are infections caused by multidrug-resistant Gram-negative bacteria including Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa for...
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Journal Article

Arginine-Rich Peptidomimetic Ampicillin/Gentamicin Conjugate To Tackle Nosocomial Biofilms: A Promising Strategy To Repurpose First-Line Antibiotics

Varvarà, Paola; Calà, Cinzia; Maida, Carmelo M.; Giuffrè, Mario; Mauro, Nicolò; Cavallaro, Gennara

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.2c00579

Combined therapy with penicillins and aminoglycosides has been proved beneficial to address many persistent bacterial infections with possible synergistic effects. However, the different pharmacokinetic profiles of these two antibiotic classes may not guarantee a concerted spatio-temporal...
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Journal Article

Urinary Glycosaminoglycans Are Associated with Recurrent UTI and Urobiome Ecology in Postmenopausal Women

Neugent, Michael L.; Hulyalkar, Neha V.; Kumar, Ashwani; Xing, Chao; Zimmern, Philippe E.; Shulaev, Vladimir; De Nisco, Nicole J.

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.3c00027 pmid:36942838

Glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides composed of repeating disaccharide units of uronic acid and amino sugars. The luminal surface of the bladder epithelium is coated with a GAG layer. These urothelial GAGs are thought to provide a protective barrier and serve...
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Journal Article

Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents

Brayton, Samantha R.; Toles, Zachary E. A.; Sanchez, Christian A.; Michaud, Marina E.; Thierer, Laura M.; Keller, Taylor M.; Risener, Caitlin J.; Quave, Cassandra L.; Wuest, William M.; Minbiole, Kevin P. C.

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.2c00624

Quaternary ammonium compounds (QACs) serve as a first line of defense against infectious pathogens. As resistance to QACs emerges in the environment, the development of next-generation disinfectants is of utmost priority for human health. Balancing antibacterial potency with environmental...
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Journal Article

The Impact of Antimicrobial Peptides on the Acinetobacter baumannii Inner Membrane Is Modulated by Lipid Polyunsaturation

MacDermott-Opeskin, Hugo I.; Wilson, Katie A.; O’Mara, Megan L.

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.2c00530 pmid:36920795

The Gram-negative pathogen Acinetobacter baumannii is a primary contributor to nosocomial multi-drug-resistant (MDR) infections. To combat the rise of MDR infections, novel features of A. baumannii need to be considered for the development of new treatment options. One such feature is the...
Available

Journal Article

Temporin-GHb-Derived Peptides Exhibit Potent Antibacterial and Antibiofilm Activities against Staphylococcus aureus In Vitro and Protect Mice from Acute Infectious Pneumonia

Jin, Xiao; Hu, Xuanyu; Jiang, Shangjun; Zhao, Ting; Zha, Yanmei; Wei, Shuangshuang; Zhao, Jianguo; Wang, Manchuriga; Zhang, Yingxia

2023 ACS Infectious Diseases

doi:10.1021/acsinfecdis.2c00544 pmid:36862073

With the continuous development of drug resistance in bacteria to traditional antibiotics, the demand for novel antibacterial agents is urgent. Antimicrobial peptides (AMPs) are promising candidates because of their unique mechanism of action and low tendency to induce drug resistance....

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