ACS Biomaterials Science and Engineering

Journal Article

Calcium Phosphate Silicate Microspheres with Soybean Lecithin as a Sustained-Release Bone Morphogenetic Protein-Delivery System for Bone Tissue Regeneration

Xue, Yaxin; Li, Yun; Zhang, Dong; Xu, Wei; Ning, Congqin;

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.2c01065 pmid:36947498

Bone morphogenetic protein (BMP) is a growth factor that effectively promotes osteogenesis. Microsphere-based drug-delivery systems can facilitate an increase in the local concentration of BMP, thus promoting bone formation. In this study, calcium phosphate silicate (CPS) microspheres were used...

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Journal Article

Hydrogel-Based Strategies for the Management of Osteomyelitis

Kuo, Chih-Yu; Lin, Tung-Yi; Yeh, Yi-Cheun

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.2c01057 pmid:36995966

Osteomyelitis is a type of bone infection caused by bacteria, with Staphylococcus sepsis being responsible for most cases. Osteomyelitis treatment generally requires a multifaceted approach that may include intervention of surgery and administration of antibacterial agents, where several...

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Journal Article

Gelatin Methacryloyl-Based Sponge with Designed Conical Microchannels for Rapidly Controlling Hemorrhage and Theoretical Verification

Cao, Lina; Ji, Zhixiao; Zhang, Bingxu; Si, Xiaoqin; Wang, Yuzhen;

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.3c00161

It remains a challenge to develop effective hemostatic products in battlefield rescue for noncompressible massive hemorrhage. Some previous research had concentrated on the modification of different materials to improve the hemostasis ability of sponges. Herein, to investigate the relationship...

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Journal Article

SiaNAl can be efficiently incorporated in glycoproteins of human mesenchymal stromal cells by metabolic glycoengineering

Mut, Jürgen; Altmann, Stephan; Reising, Sabine; Meißner-Weigl, Jutta; Driessen, Marc D.;

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.2c01534 pmid:36946521

Metabolic glycoengineering involves the stimulation of cells with functionalized monosaccharides. Glucosamine, galactosamine, and mannosamine derivatives are commercially available, but their application may lead to undirected (i.e., chemical) incorporation into proteins. However, sialic acids...

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Journal Article

Targeted Fusogenic Liposomes for Effective Tumor Delivery and Penetration of Lipophilic Cargoes

Han, Hyeonjeong; Jung, Jik-Han; Lee, Hyoungjin; Lee, Junsung; Jang, Seong-Hoon;

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.2c01490 pmid:36921244

Nanoparticle-based drug delivery has been widely used for effective anticancer treatment. However, a key challenge restricting the efficacy of nanotherapeutics is limited tissue penetration within solid tumors. Here, we report a targeted fusogenic liposome (TFL) that can selectively deliver...

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Journal Article

An Antibacterial Polypeptide Coating Prepared by In Situ Enzymatic Polymerization for Preventing Delayed Infection of Implants

Yang, Kexin; Liu, Danqing; Teng, Runxin; Li, Chang; Fan, Zhen;

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.3c00131 pmid:36877006

Delayed implant-associated infection is an important challenge, as the treatment involves a high risk of implant replacement. Mussel-inspired antimicrobial coatings can be applied to coat a variety of implants in a facile way, but the adhesive 3,4-dihydroxyphenylalanine (DOPA) group is prone to...

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Journal Article

Poly(β-amino ester) Dual-Drug-Loaded Hydrogels with Antibacterial and Osteogenic Properties for Bone Repair

Lv, Lu; Cheng, Wanting; Wang, Sining; Lin, Sihui; Dang, Jiarui;

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.2c01524 pmid:36881921

In this study, we developed a poly(β-amino ester) (PBAE) hydrogel for the double release of vancomycin (VAN) and total flavonoids of Rhizoma Drynariae (TFRD). VAN was covalently bonded to PBAE polymer chains and was released to enhance the antimicrobial effect first. TFRD chitosan (CS)...

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Journal Article

Dual-Functional Nanoplatform Based on Bimetallic Metal–Organic Frameworks for Synergistic Starvation and Chemodynamic Therapy

Xiao, Yu; Lai, Fuxuan; Xu, Mengran; Zheng, Danning; Hu, Yi;

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.2c01476 pmid:36989499

Tumor microenvironment (TME)-responsive chemodynamic therapy (CDT) mediated by nanozymes has been extensively studied in oral squamous cell carcinoma. However, the low catalytic efficiency due to insufficient H2O2 in the TME is still a major challenge for its clinical translation. Herein, we...

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Journal Article

Potential of an Aligned Porous Hydrogel Scaffold Combined with Periodontal Ligament Stem Cells or Gingival Mesenchymal Stem Cells to Promote Tissue Regeneration in Rat Periodontal Defects

Wang, Wenhao; Wang, Ao; Hu, Gaofu; Bian, Mengyao; Chen, Lili;

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.2c01440 pmid:36942823

Periodontal tissue regeneration is a major challenge in tissue engineering due to its regenerated environment complexity. It aims to regenerate not only the supporting alveolar bone and cementum around teeth but also the key connecting periodontal ligament. Herein, a constructed aligned porous...

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Journal Article

Bioinspired Antimicrobial PLA with Nanocones on the Surface for Rapid Deactivation of Omicron SARS-CoV‑2

da Silva, Daniel J.; Duran, Adriana; Cabral, Aline D.; Fonseca, Fernando L. A.; Wang, Shu Hui;

2023 ACS Biomaterials Science & Engineering

doi:10.1021/acsbiomaterials.2c01529 pmid:36881832

Bioinspired bactericidal surfaces are artificial surfaces that mimic the nanotopography of insect wings and are capable of inhibiting microbial growth by a physicomechanical mechanism. The scientific community has considered them an alternative method to design polymers with surfaces that...

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