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BackgroundTumor necrosis factor-alpha (TNF-α) is pivotal in the pathogenesis of psoriasis, an immune-mediated disease. Adalimumab is a fully human, IgG1 monoclonal antibody that inhibits TNF-α.ObjectivesThe aims of this study were to assess the efficacy and safety of adalimumab therapy for...
BackgroundThe cellular immune system plays an important role in the pathogenesis of psoriasis. The digestive system (by virtue of the profile, number and species of bacteria present at any given time and nutritional factors) can influence the status of the immune system. Bacterial pathogens...
BackgroundTopical tacrolimus is effective as monotherapy for inverse psoriasis. Its use in combination with other systemic agents may be an effective treatment for psoriasis in less sensitive areas.ObjectiveTo determine if topical tacrolimus in combination with oral acitretin is more effective...
BackgroundTo assess the consistency of infliximab (Remicade) response among different subgroups of patients with moderate to severe psoriasis, the impact of gender, obesity, age, baseline psoriasis severity, concomitant psoriatic arthritis (PsA), or prior therapies on response to infliximab was...
The chronic nature of psoriasis calls for long-term maintenance of control; thus, it is important to understand the long-term safety profile of effective therapies. We present long-term safety data for the T-cell inhibitor efalizumab in the treatment of moderate to severe psoriasis. To further...
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