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Tumor necrosis factor (TNF) blockers are highly effective in treating psoriasis and psoriatic arthritis. This article provides an update on the safety profile of TNF blockers to include new data regarding exposures during pregnancy, as well as serious infections. Currently, the published...
Itch is a common symptom among psoriasis patients, affecting up to 80% of patients. This article reviews recent advances in the pathophysiology, clinical presentation, and treatment options for psoriatic itch. English articles between 2003 and 2012, using the key words “psoriasis,” “pruritus,”...
Janus kinases (JAKs) are non-receptor tyrosine kinases that ultimately mediate the signal transduction of several key cytokines that help maintain the immune system and regulate hematopoiesis in humans. While a particular JAK deficiency has been identified in cases of autosomal recessive severe...
Psoriasis is a chronic inflammatory skin disease that affects 2.2% of Americans and is a substantial detriment on the quality of life. Psoriasis is a complex interaction between numerous immune cells and has been considered largely a T-helper type 1 (Th1) T-cell-mediated response. Although...
Drug-induced lupus erythematosus caused by anti-tumor necrosis factor (TNF)-α therapy is considered a rare event. Although different forms of lupus erythematosus have been associated with anti-TNF-α therapy, lupus panniculitis has not been reported previously. We present a patient who developed...
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