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Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules

Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor... Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules — Molecular Pharmacology var callbackToken='47379ABA8C81E3A'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules Eduardo R. Lazarowski , Richard C. Boucher and T. Kendall Harden Departments of Pharmacology and Medicine and the Cystic Fibrosis Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina <h3>Address correspondence to:</h3> Dr. T. Kendall Harden, Department of Pharmacology, University of North Carolina School of Medicine, CB#7365, Chapel Hill, NC 27599. E-mail: tkh@med.unc The concept that adenine and uridine nucleotides function as extracellular signaling molecules has been markedly expanded in the last decade. At least 15 nucleotide-activated cell surface receptors exist, and remarkably broad and varied physiological responses are known to occur downstream of nucleotide receptor activation. The significance of nucleotides as extracellular molecules also is underscored by ubiquitous distribution of several large classes of ectoenzymes that catalyze nucleotide breakdown and interconversion. Purinergic signaling was initially proposed on the basis of smooth muscle responses http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Pharmacology Am. Soc for Pharma & Experimental Therapeutics

Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules

Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules

Molecular Pharmacology , Volume 64 (4): 785 – Oct 1, 2003

Abstract

Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules — Molecular Pharmacology var callbackToken='47379ABA8C81E3A'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules Eduardo R. Lazarowski , Richard C. Boucher and T. Kendall Harden Departments of Pharmacology and Medicine and the Cystic Fibrosis Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina <h3>Address correspondence to:</h3> Dr. T. Kendall Harden, Department of Pharmacology, University of North Carolina School of Medicine, CB#7365, Chapel Hill, NC 27599. E-mail: tkh@med.unc The concept that adenine and uridine nucleotides function as extracellular signaling molecules has been markedly expanded in the last decade. At least 15 nucleotide-activated cell surface receptors exist, and remarkably broad and varied physiological responses are known to occur downstream of nucleotide receptor activation. The significance of nucleotides as extracellular molecules also is underscored by ubiquitous distribution of several large classes of ectoenzymes that catalyze nucleotide breakdown and interconversion. Purinergic signaling was initially proposed on the basis of smooth muscle responses

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References (120)

Publisher
Am. Soc for Pharma & Experimental Therapeutics
Copyright
Copyright © Molecular Pharmacology
ISSN
0026-895X
eISSN
1521-0111
DOI
10.1124/mol.64.4.785
pmid
14500734
Publisher site
See Article on Publisher Site

Abstract

Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules — Molecular Pharmacology var callbackToken='47379ABA8C81E3A'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules Eduardo R. Lazarowski , Richard C. Boucher and T. Kendall Harden Departments of Pharmacology and Medicine and the Cystic Fibrosis Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina <h3>Address correspondence to:</h3> Dr. T. Kendall Harden, Department of Pharmacology, University of North Carolina School of Medicine, CB#7365, Chapel Hill, NC 27599. E-mail: tkh@med.unc The concept that adenine and uridine nucleotides function as extracellular signaling molecules has been markedly expanded in the last decade. At least 15 nucleotide-activated cell surface receptors exist, and remarkably broad and varied physiological responses are known to occur downstream of nucleotide receptor activation. The significance of nucleotides as extracellular molecules also is underscored by ubiquitous distribution of several large classes of ectoenzymes that catalyze nucleotide breakdown and interconversion. Purinergic signaling was initially proposed on the basis of smooth muscle responses

Journal

Molecular PharmacologyAm. Soc for Pharma & Experimental Therapeutics

Published: Oct 1, 2003

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