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BRCA2 Germ-Line Mutations Are Frequent in Male Breast Cancer Patients without a Family History of the Disease

BRCA2 Germ-Line Mutations Are Frequent in Male Breast Cancer Patients without a Family History of... Breast cancer is a rare disease in men, affecting less than 0.1% of the male population. Two heritable gene defects have been associated with a predisposition to male breast cancer development, i.e. , germ-line mutations in the breast cancer susceptibility gene BRCA2 and the androgen receptor ( AR ) gene. In this study, the entire coding regions of BRCA2 and AR were screened for mutations in 34 consecutive male breast cancer patients. Five different truncating BRCA2 mutations were identified in 7 (21%) of the 34 cases, with all mutations being of germ-line origin. Three of the mutated cases carried the same mutation (4186delG), which has been found earlier in two Swedish families with multiple female breast cancer cases. Haplotype analysis supported a common ancestry of 4186delG. One mutation, 6503delTT, was found in a male carrying also a previously identified COOH-terminal polymorphic stop codon (Lys3326ter). No differences were seen between mutation carriers and noncarriers with respect to clinical stage and estrogen or progesterone receptor status. Mutation carriers tended to be younger at diagnosis. No germ-line AR mutations were found in the present material, but the number of AR polyglutamine repeats tended to be lower among mutation carriers. Most surprisingly, only one of the seven BRCA2 mutation carriers had a positive family history of breast cancer, suggesting a lower penetrance of some BRCA2 mutations or an influence of modifying factors for disease development in males and females. The present study implies that approximately one-fifth of all male breast cancer cases in the Swedish population are due to germ-line BRCA2 mutations. 1 Supported by grants from the Swedish Cancer Society, the Nordic Cancer Union, Mrs. Berta Kamprad's Foundation, the Gunnar Arvid and Elisabeth Nilsson Foundation, the John and Augusta Persson Foundation, the Hospital of Lund Foundations, and the King Gustav V Jubilee Foundation. 2 To whom requests for reprints should be addressed, at Department of Oncology, University Hospital, S-221 85 Lund, Sweden. Fax: 46 46 147327; E-mail: ake.borg@onk.lu.se. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

BRCA2 Germ-Line Mutations Are Frequent in Male Breast Cancer Patients without a Family History of the Disease

BRCA2 Germ-Line Mutations Are Frequent in Male Breast Cancer Patients without a Family History of the Disease

Cancer Research , Volume 58 (7): 1367 – Apr 1, 1998

Abstract

Breast cancer is a rare disease in men, affecting less than 0.1% of the male population. Two heritable gene defects have been associated with a predisposition to male breast cancer development, i.e. , germ-line mutations in the breast cancer susceptibility gene BRCA2 and the androgen receptor ( AR ) gene. In this study, the entire coding regions of BRCA2 and AR were screened for mutations in 34 consecutive male breast cancer patients. Five different truncating BRCA2 mutations were identified in 7 (21%) of the 34 cases, with all mutations being of germ-line origin. Three of the mutated cases carried the same mutation (4186delG), which has been found earlier in two Swedish families with multiple female breast cancer cases. Haplotype analysis supported a common ancestry of 4186delG. One mutation, 6503delTT, was found in a male carrying also a previously identified COOH-terminal polymorphic stop codon (Lys3326ter). No differences were seen between mutation carriers and noncarriers with respect to clinical stage and estrogen or progesterone receptor status. Mutation carriers tended to be younger at diagnosis. No germ-line AR mutations were found in the present material, but the number of AR polyglutamine repeats tended to be lower among mutation carriers. Most surprisingly, only one of the seven BRCA2 mutation carriers had a positive family history of breast cancer, suggesting a lower penetrance of some BRCA2 mutations or an influence of modifying factors for disease development in males and females. The present study implies that approximately one-fifth of all male breast cancer cases in the Swedish population are due to germ-line BRCA2 mutations. 1 Supported by grants from the Swedish Cancer Society, the Nordic Cancer Union, Mrs. Berta Kamprad's Foundation, the Gunnar Arvid and Elisabeth Nilsson Foundation, the John and Augusta Persson Foundation, the Hospital of Lund Foundations, and the King Gustav V Jubilee Foundation. 2 To whom requests for reprints should be addressed, at Department of Oncology, University Hospital, S-221 85 Lund, Sweden. Fax: 46 46 147327; E-mail: ake.borg@onk.lu.se.

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Publisher
American Association of Cancer Research
Copyright
Copyright © 1998 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

Breast cancer is a rare disease in men, affecting less than 0.1% of the male population. Two heritable gene defects have been associated with a predisposition to male breast cancer development, i.e. , germ-line mutations in the breast cancer susceptibility gene BRCA2 and the androgen receptor ( AR ) gene. In this study, the entire coding regions of BRCA2 and AR were screened for mutations in 34 consecutive male breast cancer patients. Five different truncating BRCA2 mutations were identified in 7 (21%) of the 34 cases, with all mutations being of germ-line origin. Three of the mutated cases carried the same mutation (4186delG), which has been found earlier in two Swedish families with multiple female breast cancer cases. Haplotype analysis supported a common ancestry of 4186delG. One mutation, 6503delTT, was found in a male carrying also a previously identified COOH-terminal polymorphic stop codon (Lys3326ter). No differences were seen between mutation carriers and noncarriers with respect to clinical stage and estrogen or progesterone receptor status. Mutation carriers tended to be younger at diagnosis. No germ-line AR mutations were found in the present material, but the number of AR polyglutamine repeats tended to be lower among mutation carriers. Most surprisingly, only one of the seven BRCA2 mutation carriers had a positive family history of breast cancer, suggesting a lower penetrance of some BRCA2 mutations or an influence of modifying factors for disease development in males and females. The present study implies that approximately one-fifth of all male breast cancer cases in the Swedish population are due to germ-line BRCA2 mutations. 1 Supported by grants from the Swedish Cancer Society, the Nordic Cancer Union, Mrs. Berta Kamprad's Foundation, the Gunnar Arvid and Elisabeth Nilsson Foundation, the John and Augusta Persson Foundation, the Hospital of Lund Foundations, and the King Gustav V Jubilee Foundation. 2 To whom requests for reprints should be addressed, at Department of Oncology, University Hospital, S-221 85 Lund, Sweden. Fax: 46 46 147327; E-mail: ake.borg@onk.lu.se.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Apr 1, 1998

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