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Influence of Cytokine Gene Polymorphisms on the Development of Prostate Cancer

Influence of Cytokine Gene Polymorphisms on the Development of Prostate Cancer Polymorphisms in the promoter regions of cytokine genes may influence prostate cancer (PC) development via regulation of the antitumor immune response and/or pathways of tumor angiogenesis. PC patients (247) and 263 controls were genotyped for interleukin (IL)-1ß-511, IL-8-251, IL-10-1082, tumor necrosis factor- -308, and vascular endothelial growth factor (VEGF)-1154 single nucleotide polymorphisms. Patient control comparisons revealed that IL-8 TT and VEGF AA genotypes were decreased in patients compared with controls 23.9 versus 32.3%; P = 0.04, odds ratio (OR) = 0.66, 95% confidence interval (CI) 0.44–0.99 and 6.3 versus 12.9%; P = 0.01, OR = 0.45, 95% CI 0.24–0.86, respectively, whereas the IL-10 AA genotype was significantly increased in patients compared with controls (31.6 versus 20.6%; P = 0.01, OR = 1.78, 95% CI 1.14–2.77). Stratification according to prognostic indicators showed association between IL-8 genotype and log prostate-specific antigen level ( P = 0.05). These results suggest that single nucleotide polymorphisms associated with differential production of IL-8, IL-10, and VEGF are risk factors for PC, possibly acting via their influence on angiogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

Influence of Cytokine Gene Polymorphisms on the Development of Prostate Cancer

Influence of Cytokine Gene Polymorphisms on the Development of Prostate Cancer

Cancer Research , Volume 62 (12): 3369 – Jun 1, 2002

Abstract

Polymorphisms in the promoter regions of cytokine genes may influence prostate cancer (PC) development via regulation of the antitumor immune response and/or pathways of tumor angiogenesis. PC patients (247) and 263 controls were genotyped for interleukin (IL)-1ß-511, IL-8-251, IL-10-1082, tumor necrosis factor- -308, and vascular endothelial growth factor (VEGF)-1154 single nucleotide polymorphisms. Patient control comparisons revealed that IL-8 TT and VEGF AA genotypes were decreased in patients compared with controls 23.9 versus 32.3%; P = 0.04, odds ratio (OR) = 0.66, 95% confidence interval (CI) 0.44–0.99 and 6.3 versus 12.9%; P = 0.01, OR = 0.45, 95% CI 0.24–0.86, respectively, whereas the IL-10 AA genotype was significantly increased in patients compared with controls (31.6 versus 20.6%; P = 0.01, OR = 1.78, 95% CI 1.14–2.77). Stratification according to prognostic indicators showed association between IL-8 genotype and log prostate-specific antigen level ( P = 0.05). These results suggest that single nucleotide polymorphisms associated with differential production of IL-8, IL-10, and VEGF are risk factors for PC, possibly acting via their influence on angiogenesis.

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Publisher
American Association of Cancer Research
Copyright
Copyright © 2002 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

Polymorphisms in the promoter regions of cytokine genes may influence prostate cancer (PC) development via regulation of the antitumor immune response and/or pathways of tumor angiogenesis. PC patients (247) and 263 controls were genotyped for interleukin (IL)-1ß-511, IL-8-251, IL-10-1082, tumor necrosis factor- -308, and vascular endothelial growth factor (VEGF)-1154 single nucleotide polymorphisms. Patient control comparisons revealed that IL-8 TT and VEGF AA genotypes were decreased in patients compared with controls 23.9 versus 32.3%; P = 0.04, odds ratio (OR) = 0.66, 95% confidence interval (CI) 0.44–0.99 and 6.3 versus 12.9%; P = 0.01, OR = 0.45, 95% CI 0.24–0.86, respectively, whereas the IL-10 AA genotype was significantly increased in patients compared with controls (31.6 versus 20.6%; P = 0.01, OR = 1.78, 95% CI 1.14–2.77). Stratification according to prognostic indicators showed association between IL-8 genotype and log prostate-specific antigen level ( P = 0.05). These results suggest that single nucleotide polymorphisms associated with differential production of IL-8, IL-10, and VEGF are risk factors for PC, possibly acting via their influence on angiogenesis.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Jun 1, 2002

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