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ras Oncogenes in Human Cancer: A Review

ras Oncogenes in Human Cancer: A Review Mutations in codon 12, 13, or 61 of one of the three ras genes, H- ras , K- ras , and N- ras , convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, although the incidence varies greatly. The highest incidences are found in adenocarcinomas of the pancreas (90%), the colon (50%), and the lung (30%); in thyroid tumors (50%); and in myeloid leukemia (30%). For some tumor types a relationship may exist between the presence of a ras mutation and clinical or histopathological features of the tumor. There is some evidence that environmental agents may be involved in the induction of the mutations. 1 This work is supported by a grant from the Dutch Cancer Society. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

ras Oncogenes in Human Cancer: A Review

Cancer Research , Volume 49 (17): 4682 – Sep 1, 1989

ras Oncogenes in Human Cancer: A Review

Cancer Research , Volume 49 (17): 4682 – Sep 1, 1989

Abstract

Mutations in codon 12, 13, or 61 of one of the three ras genes, H- ras , K- ras , and N- ras , convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, although the incidence varies greatly. The highest incidences are found in adenocarcinomas of the pancreas (90%), the colon (50%), and the lung (30%); in thyroid tumors (50%); and in myeloid leukemia (30%). For some tumor types a relationship may exist between the presence of a ras mutation and clinical or histopathological features of the tumor. There is some evidence that environmental agents may be involved in the induction of the mutations. 1 This work is supported by a grant from the Dutch Cancer Society.

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Publisher
American Association of Cancer Research
Copyright
Copyright © 1989 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

Mutations in codon 12, 13, or 61 of one of the three ras genes, H- ras , K- ras , and N- ras , convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, although the incidence varies greatly. The highest incidences are found in adenocarcinomas of the pancreas (90%), the colon (50%), and the lung (30%); in thyroid tumors (50%); and in myeloid leukemia (30%). For some tumor types a relationship may exist between the presence of a ras mutation and clinical or histopathological features of the tumor. There is some evidence that environmental agents may be involved in the induction of the mutations. 1 This work is supported by a grant from the Dutch Cancer Society.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Sep 1, 1989

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