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Species Differences in the Effect of Benzo(a)pyrene-Ferric Oxide on the Respiratory Tract of Rats and Hamsters

Species Differences in the Effect of Benzo(a)pyrene-Ferric Oxide on the Respiratory Tract of Rats... When given intratracheal injections of a suspension of benzo( a )pyrene-ferric oxide, rats and hamsters showed striking species differences in the response of their respiratory tracts to the carcinogen. Hamsters produced squamous metaplasia of the trachea and large bronchi; in contrast, squamous cell nodules of bronchioloalveolar origin developed in rats within a few weeks after carcinogen application. The different sites of the early proliferative and metaplastic responses correlated in their location with the sites of later tumor development. There were no obvious differences between the two species in retention of benzo( a )pyrene in the lungs or tracheas. A species difference was observed, however, in the localization of the benzo( a )pyrene in the tracheal tissues using ultraviolet fluorescence microscopy. Carcinogen was found to be present in the epithelium of hamsters but not in the epithelium of rats, suggesting a species difference in penetration of carcinogen from the lumen into the tracheal tissues. 1 Research supported jointly by the Carcinogenesis Program of the National Cancer Institute and the United States Atomic Energy Commission under contract with the Union Carbide Corporation. 2 Present address: Department of Pathology, University of Chicago, 950 East 59th Street, Chicago, Ill. 60637. To whom reprint requests should be addressed. 3 Supported by the Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

Species Differences in the Effect of Benzo(a)pyrene-Ferric Oxide on the Respiratory Tract of Rats and Hamsters

Cancer Research , Volume 35 (7): 1654 – Jul 1, 1975

Species Differences in the Effect of Benzo(a)pyrene-Ferric Oxide on the Respiratory Tract of Rats and Hamsters

Cancer Research , Volume 35 (7): 1654 – Jul 1, 1975

Abstract

When given intratracheal injections of a suspension of benzo( a )pyrene-ferric oxide, rats and hamsters showed striking species differences in the response of their respiratory tracts to the carcinogen. Hamsters produced squamous metaplasia of the trachea and large bronchi; in contrast, squamous cell nodules of bronchioloalveolar origin developed in rats within a few weeks after carcinogen application. The different sites of the early proliferative and metaplastic responses correlated in their location with the sites of later tumor development. There were no obvious differences between the two species in retention of benzo( a )pyrene in the lungs or tracheas. A species difference was observed, however, in the localization of the benzo( a )pyrene in the tracheal tissues using ultraviolet fluorescence microscopy. Carcinogen was found to be present in the epithelium of hamsters but not in the epithelium of rats, suggesting a species difference in penetration of carcinogen from the lumen into the tracheal tissues. 1 Research supported jointly by the Carcinogenesis Program of the National Cancer Institute and the United States Atomic Energy Commission under contract with the Union Carbide Corporation. 2 Present address: Department of Pathology, University of Chicago, 950 East 59th Street, Chicago, Ill. 60637. To whom reprint requests should be addressed. 3 Supported by the Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela.

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Publisher
American Association of Cancer Research
Copyright
Copyright © 1975 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

When given intratracheal injections of a suspension of benzo( a )pyrene-ferric oxide, rats and hamsters showed striking species differences in the response of their respiratory tracts to the carcinogen. Hamsters produced squamous metaplasia of the trachea and large bronchi; in contrast, squamous cell nodules of bronchioloalveolar origin developed in rats within a few weeks after carcinogen application. The different sites of the early proliferative and metaplastic responses correlated in their location with the sites of later tumor development. There were no obvious differences between the two species in retention of benzo( a )pyrene in the lungs or tracheas. A species difference was observed, however, in the localization of the benzo( a )pyrene in the tracheal tissues using ultraviolet fluorescence microscopy. Carcinogen was found to be present in the epithelium of hamsters but not in the epithelium of rats, suggesting a species difference in penetration of carcinogen from the lumen into the tracheal tissues. 1 Research supported jointly by the Carcinogenesis Program of the National Cancer Institute and the United States Atomic Energy Commission under contract with the Union Carbide Corporation. 2 Present address: Department of Pathology, University of Chicago, 950 East 59th Street, Chicago, Ill. 60637. To whom reprint requests should be addressed. 3 Supported by the Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Jul 1, 1975

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