Get 20M+ Full-Text Papers For Less Than $1.50/day. Subscribe now for You or Your Team.

Learn More →

Telomere Length in Peripheral Blood Leukocytes and Lung Cancer Risk: A Large Case–Control Study in Caucasians

Telomere Length in Peripheral Blood Leukocytes and Lung Cancer Risk: A Large Case–Control Study... Telomere dysfunction is a crucial event in malignant transformation and tumorigenesis. Telomere length in peripheral blood leukocytes has been associated with lung cancer risk, but the relationship has remained controversial. In this study, we investigated whether the association might be confounded by study of different histological subtypes of lung cancer. We measured relative telomere lengths in patients in a large case–control study of lung cancer and performed stratified analyses according to the two major histologic subtypes (adenocarcinoma and squamous cell carcinoma (SCC)). Notably, patients with adenocarcinoma had longer telomeres than controls, whereas patients with SCC had shorter telomeres compared with controls. Long telomeres were associated with increased risk of adenocarcinoma, with the highest risk associated with female sex, younger age (<60 years), and lighter smoking (<30 pack-years). In contrast, long telomeres were protective against SCC, particularly in male patients. Our results extend the concept that telomere length affects risk of lung cancer in a manner that differs with histologic subtype. Cancer Res; 74(9); 2476–86. ©2014 AACR . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

Telomere Length in Peripheral Blood Leukocytes and Lung Cancer Risk: A Large Case–Control Study in Caucasians

Telomere Length in Peripheral Blood Leukocytes and Lung Cancer Risk: A Large Case–Control Study in Caucasians

Cancer Research , Volume 74 (9): 2476 – May 1, 2014

Abstract

Telomere dysfunction is a crucial event in malignant transformation and tumorigenesis. Telomere length in peripheral blood leukocytes has been associated with lung cancer risk, but the relationship has remained controversial. In this study, we investigated whether the association might be confounded by study of different histological subtypes of lung cancer. We measured relative telomere lengths in patients in a large case–control study of lung cancer and performed stratified analyses according to the two major histologic subtypes (adenocarcinoma and squamous cell carcinoma (SCC)). Notably, patients with adenocarcinoma had longer telomeres than controls, whereas patients with SCC had shorter telomeres compared with controls. Long telomeres were associated with increased risk of adenocarcinoma, with the highest risk associated with female sex, younger age (<60 years), and lighter smoking (<30 pack-years). In contrast, long telomeres were protective against SCC, particularly in male patients. Our results extend the concept that telomere length affects risk of lung cancer in a manner that differs with histologic subtype. Cancer Res; 74(9); 2476–86. ©2014 AACR .

Loading next page...
 
/lp/american-association-of-cancer-research/telomere-length-in-peripheral-blood-leukocytes-and-lung-cancer-risk-a-lAJBFAJRz1

References (56)

Publisher
American Association of Cancer Research
Copyright
Copyright © 2014 American Association for Cancer Research
ISSN
0008-5472
eISSN
1538-7445
DOI
10.1158/0008-5472.CAN-13-2968
pmid
24618342
Publisher site
See Article on Publisher Site

Abstract

Telomere dysfunction is a crucial event in malignant transformation and tumorigenesis. Telomere length in peripheral blood leukocytes has been associated with lung cancer risk, but the relationship has remained controversial. In this study, we investigated whether the association might be confounded by study of different histological subtypes of lung cancer. We measured relative telomere lengths in patients in a large case–control study of lung cancer and performed stratified analyses according to the two major histologic subtypes (adenocarcinoma and squamous cell carcinoma (SCC)). Notably, patients with adenocarcinoma had longer telomeres than controls, whereas patients with SCC had shorter telomeres compared with controls. Long telomeres were associated with increased risk of adenocarcinoma, with the highest risk associated with female sex, younger age (<60 years), and lighter smoking (<30 pack-years). In contrast, long telomeres were protective against SCC, particularly in male patients. Our results extend the concept that telomere length affects risk of lung cancer in a manner that differs with histologic subtype. Cancer Res; 74(9); 2476–86. ©2014 AACR .

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: May 1, 2014

There are no references for this article.