Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers

Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B... ORIGINAL ARTICLE Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers Carl Ernst, MSc; Vesselina Deleva, MSc; Xiaoming Deng, MD; Adolfo Sequeira, PhD; Amanda Pomarenski, BSc; Tim Klempan, PhD; Neil Ernst, MSc; Remi Quirion, PhD; Alain Gratton, PhD; Moshe Szyf, PhD; Gustavo Turecki, MD, PhD Context: Although most of the effort to understand the periments were performed to control for drug and alco- neurobiology of depressive states and suicide has fo- hol effects. Genetic and epigenetic studies were per- cused on neuronal processes, recent studies suggest formed by means of direct sequencing and bisulfite that astroglial dysfunction may play an important role. mapping. A truncated variant of the tropomyosin-related kinase B (TrkB.T1) is expressed in astrocytes, and brain-derived Results: We found that 10 of 28 suicide completers (36%) neurotrophic factor–TrkB signaling has been linked to demonstrated significant decreases in different probe sets mood disorders. specific to TrkB.T1 in Brodmann areas 8 and 9. These findings were generalizable to other frontal regions but Objective: To test the hypothesis that TrkB.T1 expres- not to the cerebellum. The decrease in TrkB expression sion is downregulated in suicide completers and that this was specific http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers

Loading next page...
 
/lp/american-medical-association/alternative-splicing-methylation-state-and-expression-profile-of-xZ30YYVXqZ

References (78)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archpsyc.66.1.22
pmid
19124685
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers Carl Ernst, MSc; Vesselina Deleva, MSc; Xiaoming Deng, MD; Adolfo Sequeira, PhD; Amanda Pomarenski, BSc; Tim Klempan, PhD; Neil Ernst, MSc; Remi Quirion, PhD; Alain Gratton, PhD; Moshe Szyf, PhD; Gustavo Turecki, MD, PhD Context: Although most of the effort to understand the periments were performed to control for drug and alco- neurobiology of depressive states and suicide has fo- hol effects. Genetic and epigenetic studies were per- cused on neuronal processes, recent studies suggest formed by means of direct sequencing and bisulfite that astroglial dysfunction may play an important role. mapping. A truncated variant of the tropomyosin-related kinase B (TrkB.T1) is expressed in astrocytes, and brain-derived Results: We found that 10 of 28 suicide completers (36%) neurotrophic factor–TrkB signaling has been linked to demonstrated significant decreases in different probe sets mood disorders. specific to TrkB.T1 in Brodmann areas 8 and 9. These findings were generalizable to other frontal regions but Objective: To test the hypothesis that TrkB.T1 expres- not to the cerebellum. The decrease in TrkB expression sion is downregulated in suicide completers and that this was specific

Journal

JAMA PsychiatryAmerican Medical Association

Published: Jan 1, 2009

There are no references for this article.