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Association Between BRCA1and BRCA2Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer

Association Between BRCA1and BRCA2Mutations and Survival in Women With Invasive Epithelial... ORIGINAL CONTRIBUTION Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer Kelly L. Bolton, PhD, Georgia Chenevix- Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) Trench, PhD, Cindy Goh, BA, Siegal Sadetzki, carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested MD, MPH, Susan J. Ramus, PhD, Beth Y. that BRCA2-related EOC was associated with an improved prognosis, but the effect Karlan, MD, Diether Lambrechts, PhD, Evelyn of BRCA1 remains unclear. Despierre, MD, Daniel Barrowdale, BSc, Lesley Objective To characterize the survival of BRCA carriers with EOC compared with McGuffog, Sue Healey, BSc, Douglas F. Easton, noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar sur- PhD, Olga Sinilnikova, PhD, Javier Benı´tez, vival patterns. PhD, Marı´a J. Garcı´a, PhD, Susan Neuhausen, Design, Setting, and Participants A pooled analysis of 26 observational studies PhD, Mitchell H. Gail, MD, PhD, Patricia on the survival of women with ovarian cancer, which included data from 1213 EOC Hartge, ScD, Susan Peock, PhD, Debra Frost, cases with pathogenic germline mutations in BRCA1 (n = 909) or BRCA2 (n = 304) and ONC, D. Gareth Evans, MBBS, MRCP, MD, from 2666 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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References (37)

Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2012.20
pmid
22274685
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer Kelly L. Bolton, PhD, Georgia Chenevix- Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) Trench, PhD, Cindy Goh, BA, Siegal Sadetzki, carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested MD, MPH, Susan J. Ramus, PhD, Beth Y. that BRCA2-related EOC was associated with an improved prognosis, but the effect Karlan, MD, Diether Lambrechts, PhD, Evelyn of BRCA1 remains unclear. Despierre, MD, Daniel Barrowdale, BSc, Lesley Objective To characterize the survival of BRCA carriers with EOC compared with McGuffog, Sue Healey, BSc, Douglas F. Easton, noncarriers and to determine whether BRCA1 and BRCA2 carriers show similar sur- PhD, Olga Sinilnikova, PhD, Javier Benı´tez, vival patterns. PhD, Marı´a J. Garcı´a, PhD, Susan Neuhausen, Design, Setting, and Participants A pooled analysis of 26 observational studies PhD, Mitchell H. Gail, MD, PhD, Patricia on the survival of women with ovarian cancer, which included data from 1213 EOC Hartge, ScD, Susan Peock, PhD, Debra Frost, cases with pathogenic germline mutations in BRCA1 (n = 909) or BRCA2 (n = 304) and ONC, D. Gareth Evans, MBBS, MRCP, MD, from 2666

Journal

JAMAAmerican Medical Association

Published: Jan 25, 2012

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