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Association of Risk-Reducing Surgery in BRCA1or BRCA2Mutation Carriers With Cancer Risk and Mortality

Association of Risk-Reducing Surgery in BRCA1or BRCA2Mutation Carriers With Cancer Risk and... ORIGINAL CONTRIBUTION Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers With Cancer Risk and Mortality Susan M. Domchek, MD Context Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 Tara M. Friebel, MPH or BRCA2 mutations to reduce their risks of breast and ovarian cancer. Christian F. Singer, MD, MPH Objective To estimate risk and mortality reduction stratified by mutation and prior cancer status. D. Gareth Evans, MD Design, Setting, and Participants Prospective, multicenter cohort study of 2482 Henry T. Lynch, MD women with BRCA1 or BRCA2 mutations ascertained between 1974 and 2008. The study Claudine Isaacs, MD was conducted at 22 clinical and research genetics centers in Europe and North America to assess the relationship of risk-reducing mastectomy or salpingo-oophorectomy with Judy E. Garber, MD, MPH cancer outcomes. The women were followed up until the end of 2009. Susan L. Neuhausen, PhD Main Outcomes Measures Breast and ovarian cancer risk, cancer-specific mor- Ellen Matloff, MS tality, and overall mortality. Rosalind Eeles, PhD Results No breast cancers were diagnosed in the 247 women with risk-reducing mas- tectomy compared with 98 women of 1372 diagnosed with breast cancer who did Gabriella Pichert, MD not have risk-reducing mastectomy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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References (68)

Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2010.1237
pmid
20810374
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers With Cancer Risk and Mortality Susan M. Domchek, MD Context Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 Tara M. Friebel, MPH or BRCA2 mutations to reduce their risks of breast and ovarian cancer. Christian F. Singer, MD, MPH Objective To estimate risk and mortality reduction stratified by mutation and prior cancer status. D. Gareth Evans, MD Design, Setting, and Participants Prospective, multicenter cohort study of 2482 Henry T. Lynch, MD women with BRCA1 or BRCA2 mutations ascertained between 1974 and 2008. The study Claudine Isaacs, MD was conducted at 22 clinical and research genetics centers in Europe and North America to assess the relationship of risk-reducing mastectomy or salpingo-oophorectomy with Judy E. Garber, MD, MPH cancer outcomes. The women were followed up until the end of 2009. Susan L. Neuhausen, PhD Main Outcomes Measures Breast and ovarian cancer risk, cancer-specific mor- Ellen Matloff, MS tality, and overall mortality. Rosalind Eeles, PhD Results No breast cancers were diagnosed in the 247 women with risk-reducing mas- tectomy compared with 98 women of 1372 diagnosed with breast cancer who did Gabriella Pichert, MD not have risk-reducing mastectomy.

Journal

JAMAAmerican Medical Association

Published: Sep 1, 2010

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