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Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy

Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With... ORIGINAL CONTRIBUTION Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy A Randomized Clinical Trial Ellen M. Lavoie Smith, PhD Importance There are no known effective treatments for painful chemotherapy- Herbert Pang, PhD induced peripheral neuropathy. Constance Cirrincione, MS Objective To determine the effect of duloxetine, 60 mg daily, on average pain severity. Stewart Fleishman, MD Design, Setting, and Patients Randomized, double-blind, placebo-controlled cross- over trial at 8 National Cancer Institute (NCI)–funded cooperative research networks Electra D. Paskett, PhD that enrolled 231 patients who were 25 years or older being treated at community Tim Ahles, PhD and academic settings between April 2008 and March 2011. Study follow-up was com- pleted July 2012. Stratified by chemotherapeutic drug and comorbid pain risk, pa- Linda R. Bressler, PharmD tients were randomized to receive either duloxetine followed by placebo or placebo Camilo E. Fadul, MD followed by duloxetine. Eligibility required that patients have grade 1 or higher sen- Chetaye Knox, BS sory neuropathy according to the NCI Common Terminology Criteria for Adverse Events and at least 4 on a scale of 0 to 10, representing average chemotherapy-induced pain, Nguyet Le-Lindqwister, MD after paclitaxel, other taxane, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy

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References (74)

Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2013.2813
pmid
23549581
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy A Randomized Clinical Trial Ellen M. Lavoie Smith, PhD Importance There are no known effective treatments for painful chemotherapy- Herbert Pang, PhD induced peripheral neuropathy. Constance Cirrincione, MS Objective To determine the effect of duloxetine, 60 mg daily, on average pain severity. Stewart Fleishman, MD Design, Setting, and Patients Randomized, double-blind, placebo-controlled cross- over trial at 8 National Cancer Institute (NCI)–funded cooperative research networks Electra D. Paskett, PhD that enrolled 231 patients who were 25 years or older being treated at community Tim Ahles, PhD and academic settings between April 2008 and March 2011. Study follow-up was com- pleted July 2012. Stratified by chemotherapeutic drug and comorbid pain risk, pa- Linda R. Bressler, PharmD tients were randomized to receive either duloxetine followed by placebo or placebo Camilo E. Fadul, MD followed by duloxetine. Eligibility required that patients have grade 1 or higher sen- Chetaye Knox, BS sory neuropathy according to the NCI Common Terminology Criteria for Adverse Events and at least 4 on a scale of 0 to 10, representing average chemotherapy-induced pain, Nguyet Le-Lindqwister, MD after paclitaxel, other taxane,

Journal

JAMAAmerican Medical Association

Published: Apr 3, 2013

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