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Infections With Oseltamivir-Resistant Influenza A(H1N1) Virus in the United States

Infections With Oseltamivir-Resistant Influenza A(H1N1) Virus in the United States ORIGINAL CONTRIBUTION Infections With Oseltamivir-Resistant Influenza A(H1N1) Virus in the United States Nila J. Dharan, MD Context During the 2007-2008 influenza season, oseltamivir resistance among in- fluenza A(H1N1) viruses increased significantly for the first time worldwide. Early sur- Larisa V. Gubareva, PhD veillance data suggest that the prevalence of oseltamivir resistance among A(H1N1) John J. Meyer, MPH viruses will most likely be higher during the 2008-2009 season. Margaret Okomo-Adhiambo, PhD Objectives To describe patients infected with oseltamivir-resistant influenza A(H1N1) Reginald C. McClinton, MPH virus and to determine whether there were any differences between these patients and patients infected with oseltamivir-susceptible A(H1N1) virus in demographic or epide- Steven A. Marshall, MS miological characteristics, clinical symptoms, severity of illness, or clinical outcomes. Kirsten St. George, MAppSc, PhD Design, Setting, and Patients Influenza A(H1N1) viruses that were identified and Scott Epperson, MPH submitted to the Centers for Disease Control and Prevention by US public health labo- ratories between September 30, 2007, and May 17, 2008, and between September Lynnette Brammer, MPH 28, 2008, and February 19, 2009, were tested as part of ongoing surveillance. Os- Alexander I. Klimov, PhD eltamivir resistance was determined by neuraminidase inhibition assay and pyrose- Joseph S. Bresee, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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References (33)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2009.294
pmid
19255110
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Infections With Oseltamivir-Resistant Influenza A(H1N1) Virus in the United States Nila J. Dharan, MD Context During the 2007-2008 influenza season, oseltamivir resistance among in- fluenza A(H1N1) viruses increased significantly for the first time worldwide. Early sur- Larisa V. Gubareva, PhD veillance data suggest that the prevalence of oseltamivir resistance among A(H1N1) John J. Meyer, MPH viruses will most likely be higher during the 2008-2009 season. Margaret Okomo-Adhiambo, PhD Objectives To describe patients infected with oseltamivir-resistant influenza A(H1N1) Reginald C. McClinton, MPH virus and to determine whether there were any differences between these patients and patients infected with oseltamivir-susceptible A(H1N1) virus in demographic or epide- Steven A. Marshall, MS miological characteristics, clinical symptoms, severity of illness, or clinical outcomes. Kirsten St. George, MAppSc, PhD Design, Setting, and Patients Influenza A(H1N1) viruses that were identified and Scott Epperson, MPH submitted to the Centers for Disease Control and Prevention by US public health labo- ratories between September 30, 2007, and May 17, 2008, and between September Lynnette Brammer, MPH 28, 2008, and February 19, 2009, were tested as part of ongoing surveillance. Os- Alexander I. Klimov, PhD eltamivir resistance was determined by neuraminidase inhibition assay and pyrose- Joseph S. Bresee,

Journal

JAMAAmerican Medical Association

Published: Mar 11, 2009

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