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Neurologic Signs in Senescence

Neurologic Signs in Senescence Abstract • We examined 2,029 volunteers 50 to 93 years of age in a cross-sectional study of nine bedside neurologic tests to determine the frequency of "abnormal" responses in uncomplicated aging (senescence). Rates of abnormal responses remained constant until age 70 years, after which they increased significantly. The number of abnormal signs per subject also increased, especially over 70 years of age. These results provide normative data against which these signs may be compared when applied as a clinical screening battery for diffuse cerebral dysfunction. References 1. Jenkyn LR, Reeves AG: Neurologic signs in uncomplicated aging (senescence) . Semin Neurol 1981;1:21-30.Crossref 2. Impallomeni M, Flynn MD, Kenny RA, et al: The elderly and their ankle jerks . Lancet 1984; 1:670-672.Crossref 3. Jenkyn LR, Reeves AG: Signs of cortical disinhibition in neuropsychiatric disorders . Psychiatr Med 1984;1:389-405. 4. Jenkyn LR, Reeves AG: Clinical signs in diffuse cerebral dysfunction . J Neurol Neurosurg Psychiatry 1977;41:956-966.Crossref 5. Jenkyn LR, Reeves AG: Clinical signs in the diagnosis of diffuse cerebral dysfunction , in Maletta GJ, Pirozzolo FJ, (eds): Advances in Neurogerontology , vol 2. New York, Praeger, 1981, pp 95-104. 6. Katzman R: The prevalence and malignancy of Alzheimer's disease: A major killer . Arch Neurol 1976;33:217-218.Crossref 7. Chamberlain W: Restriction in upward gaze with advancing age . Am J Ophthalmol 1971; 71:341-346. 8. Hutton T, Nagel JA, Loewenson RB: Variables affecting eye tracking performance . Electroencephalogr Clin Neurophysiol 1983;56:414-419.Crossref 9. Jenkyn LR, Reeves AG: Voluntary and reflex vertical gaze , in Smith JL (ed): Neuro-ophthalmology Update, 1980 . New York, Pergamon Press, 1979, pp 466-470. 10. Cohen MM, Lessel S: The neuro-ophthalmology of aging , in Albert ML (ed): Clinical neurology of aging . New York, Oxford University Press, 1984, pp 313-344. 11. Rushworth G: Observations on blink reflexes . J Neurol Neurosurg Psychiatry 1962; 25:93-108.Crossref 12. Jacobs L, Gossman MD: Three primitive reflexes in normal adults . Neurology 1980;30:184-188.Crossref 13. Gossman MD, Jacobs L: Three primitive reflexes in parkinsonism patients . Neurology 1980;30:189-192.Crossref 14. Pearce J, Aziz H, Gallagher JC: Primitive reflex activity in primary and symptomatic parkinsonism . J Neurol Neurosurg Psychiatry 1968; 31:501-508.Crossref 15. Tweedy J, Reding M, Garcia C, et al: Significance of cortical disinhibition signs . Neurology 1982;32:169-173.Crossref 16. Wagner HN: Probing the chemistry of the mind . N Engl J Med 1985;312:44-46.Crossref 17. Sirkin DW, Schallert T, Teitelbaum P: Involvement of the pontine reticular formation in head movements and labyrinthine righting reflexes in the rat . Exp Neurol 1980;69:435-457.Crossref 18. Ochs R, Gloor P, Quesney F, et al: Does head-turning during a seizure have lateralizing or localizing significance . Neurology 1984;34:884-890.Crossref 19. Jenkyn LR, Walsh DB, Walsh BT, et al: The nuchocephalic reflex . J Neurol Neurosurg Psychiatry 1975;38:561-566.Crossref 20. Daroff RB, Troost BT: Supranuclear disorders of eye movements , in Glaser JS (ed): Neuro-ophthalmology . Hagerstown, Md, Harper & Row Publishers Inc, 1978, pp 201-218. 21. Leigh RJ, Tusa RJ: Disturbance of smooth pursuit caused by infarction of occipitoparietal cortex . Ann Neurol 1985;17:185-187.Crossref 22. White OB, Saint-Cyr JA, Tomlinson RD, et al: Ocular motor deficits in Parkinson's disease: II. Control of the saccadic and smooth pursuit systems . Brain 1983;106:571-587.Crossref 23. Jensen JPA, Gron U, Pakkenberg: Comparison of three primitive reflexes in neurological patients and in normal individuals . J Neurol Neurosurg Psychiatry 1983;46:162-167.Crossref 24. Isakov E, Sazbon L, Costeff H, et al: The diagnostic value of three common primitive reflexes . Eur Neurol 1984;23:17-21.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

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References (26)

Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1985.04060110036012
Publisher site
See Article on Publisher Site

Abstract

Abstract • We examined 2,029 volunteers 50 to 93 years of age in a cross-sectional study of nine bedside neurologic tests to determine the frequency of "abnormal" responses in uncomplicated aging (senescence). Rates of abnormal responses remained constant until age 70 years, after which they increased significantly. The number of abnormal signs per subject also increased, especially over 70 years of age. These results provide normative data against which these signs may be compared when applied as a clinical screening battery for diffuse cerebral dysfunction. References 1. Jenkyn LR, Reeves AG: Neurologic signs in uncomplicated aging (senescence) . Semin Neurol 1981;1:21-30.Crossref 2. Impallomeni M, Flynn MD, Kenny RA, et al: The elderly and their ankle jerks . Lancet 1984; 1:670-672.Crossref 3. Jenkyn LR, Reeves AG: Signs of cortical disinhibition in neuropsychiatric disorders . Psychiatr Med 1984;1:389-405. 4. Jenkyn LR, Reeves AG: Clinical signs in diffuse cerebral dysfunction . J Neurol Neurosurg Psychiatry 1977;41:956-966.Crossref 5. Jenkyn LR, Reeves AG: Clinical signs in the diagnosis of diffuse cerebral dysfunction , in Maletta GJ, Pirozzolo FJ, (eds): Advances in Neurogerontology , vol 2. New York, Praeger, 1981, pp 95-104. 6. Katzman R: The prevalence and malignancy of Alzheimer's disease: A major killer . Arch Neurol 1976;33:217-218.Crossref 7. Chamberlain W: Restriction in upward gaze with advancing age . Am J Ophthalmol 1971; 71:341-346. 8. Hutton T, Nagel JA, Loewenson RB: Variables affecting eye tracking performance . Electroencephalogr Clin Neurophysiol 1983;56:414-419.Crossref 9. Jenkyn LR, Reeves AG: Voluntary and reflex vertical gaze , in Smith JL (ed): Neuro-ophthalmology Update, 1980 . New York, Pergamon Press, 1979, pp 466-470. 10. Cohen MM, Lessel S: The neuro-ophthalmology of aging , in Albert ML (ed): Clinical neurology of aging . New York, Oxford University Press, 1984, pp 313-344. 11. Rushworth G: Observations on blink reflexes . J Neurol Neurosurg Psychiatry 1962; 25:93-108.Crossref 12. Jacobs L, Gossman MD: Three primitive reflexes in normal adults . Neurology 1980;30:184-188.Crossref 13. Gossman MD, Jacobs L: Three primitive reflexes in parkinsonism patients . Neurology 1980;30:189-192.Crossref 14. Pearce J, Aziz H, Gallagher JC: Primitive reflex activity in primary and symptomatic parkinsonism . J Neurol Neurosurg Psychiatry 1968; 31:501-508.Crossref 15. Tweedy J, Reding M, Garcia C, et al: Significance of cortical disinhibition signs . Neurology 1982;32:169-173.Crossref 16. Wagner HN: Probing the chemistry of the mind . N Engl J Med 1985;312:44-46.Crossref 17. Sirkin DW, Schallert T, Teitelbaum P: Involvement of the pontine reticular formation in head movements and labyrinthine righting reflexes in the rat . Exp Neurol 1980;69:435-457.Crossref 18. Ochs R, Gloor P, Quesney F, et al: Does head-turning during a seizure have lateralizing or localizing significance . Neurology 1984;34:884-890.Crossref 19. Jenkyn LR, Walsh DB, Walsh BT, et al: The nuchocephalic reflex . J Neurol Neurosurg Psychiatry 1975;38:561-566.Crossref 20. Daroff RB, Troost BT: Supranuclear disorders of eye movements , in Glaser JS (ed): Neuro-ophthalmology . Hagerstown, Md, Harper & Row Publishers Inc, 1978, pp 201-218. 21. Leigh RJ, Tusa RJ: Disturbance of smooth pursuit caused by infarction of occipitoparietal cortex . Ann Neurol 1985;17:185-187.Crossref 22. White OB, Saint-Cyr JA, Tomlinson RD, et al: Ocular motor deficits in Parkinson's disease: II. Control of the saccadic and smooth pursuit systems . Brain 1983;106:571-587.Crossref 23. Jensen JPA, Gron U, Pakkenberg: Comparison of three primitive reflexes in neurological patients and in normal individuals . J Neurol Neurosurg Psychiatry 1983;46:162-167.Crossref 24. Isakov E, Sazbon L, Costeff H, et al: The diagnostic value of three common primitive reflexes . Eur Neurol 1984;23:17-21.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Dec 1, 1985

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