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Telomere Length and Risk of Incident Cancer and Cancer Mortality

Telomere Length and Risk of Incident Cancer and Cancer Mortality PRELIMINARY COMMUNICATION Telomere Length and Risk of Incident Cancer and Cancer Mortality Peter Willeit, MD Context Telomeres are essential to preserve the integrity of the genome. Critically short telomeres lead to replicative cell senescence and chromosomal instability and Johann Willeit, MD may thereby increase cancer risk. Agnes Mayr, MD Objective To determine the association between baseline telomere length and in- Siegfried Weger, MD cident cancer and cancer mortality. Friedrich Oberhollenzer, MD Design, Setting, and Participants Leukocyte telomere length was measured by Anita Brandstätter, PhD quantitative polymerase chain reaction in 787 participants free of cancer at baseline in 1995 from the prospective, population-based Bruneck Study in Italy. Florian Kronenberg, MD Main Outcome Measures Incident cancer and cancer mortality over a follow-up Stefan Kiechl, MD period of 10 years (1995-2005 with a follow-up rate of 100%). Results A total of 92 of 787 participants (11.7%) developed cancer (incidence rate, ELOMERES ARE NUCLEOPROTEIN 13.3 per 1000 person-years). Short telomere length at baseline was associated with in- complexes at the extreme ends cident cancer independently of standard cancer risk factors (multivariable hazard ratio of linear chromosomes implicit [HR] per 1-SD decrease in log -transformed telomere length, 1.60; 95% confidence in- Tin the maintenance http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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References (34)

Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2010.897
pmid
20606151
Publisher site
See Article on Publisher Site

Abstract

PRELIMINARY COMMUNICATION Telomere Length and Risk of Incident Cancer and Cancer Mortality Peter Willeit, MD Context Telomeres are essential to preserve the integrity of the genome. Critically short telomeres lead to replicative cell senescence and chromosomal instability and Johann Willeit, MD may thereby increase cancer risk. Agnes Mayr, MD Objective To determine the association between baseline telomere length and in- Siegfried Weger, MD cident cancer and cancer mortality. Friedrich Oberhollenzer, MD Design, Setting, and Participants Leukocyte telomere length was measured by Anita Brandstätter, PhD quantitative polymerase chain reaction in 787 participants free of cancer at baseline in 1995 from the prospective, population-based Bruneck Study in Italy. Florian Kronenberg, MD Main Outcome Measures Incident cancer and cancer mortality over a follow-up Stefan Kiechl, MD period of 10 years (1995-2005 with a follow-up rate of 100%). Results A total of 92 of 787 participants (11.7%) developed cancer (incidence rate, ELOMERES ARE NUCLEOPROTEIN 13.3 per 1000 person-years). Short telomere length at baseline was associated with in- complexes at the extreme ends cident cancer independently of standard cancer risk factors (multivariable hazard ratio of linear chromosomes implicit [HR] per 1-SD decrease in log -transformed telomere length, 1.60; 95% confidence in- Tin the maintenance

Journal

JAMAAmerican Medical Association

Published: Jul 7, 2010

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