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The Significance of Local Control in the Primary Treatment of Breast Cancer: Lucy Wortham James Clinical Research Award

The Significance of Local Control in the Primary Treatment of Breast Cancer: Lucy Wortham James... Abstract • Two sequential clinical trials were carried out to compare wide excision with radical mastectomy in patients with early breast cancer with clinically negative nodes. In the first study there was an increased incidence of local recurrence in patients who had wide excision, but distant recurrence and survival were unaltered. In the second study, the distant recurrence and survival rates were also significantly impaired. A new analysis showed that there were significantly more patients with T1 tumors in the second study than in the first. Comparison of treatments by T status indicates that radical mastectomy gives significantly better results in patients with T1 tumors. There is no difference between the results of the two treatments in patients with T2 tumors. We comment on the implications of these findings for conservation treatment of early breast cancer. (Arch Surg 1987;122:1244-1247) References 1. Mustakallio S: Conservative treatment of breast cancer . Clin Radiol 1972;23:110-116.Crossref 2. Crile G: Treatment of breast cancer by local excision . Am J Surg 1965;109:400-403.Crossref 3. Fleming J, Atkinson L: Carcinoma of the breast . Med J Aust 1961;181-287. 4. Dixon RA: Results of treatment of breast cancer in South-east England . Br J Cancer 1969;23:9-20.Crossref 5. Atkins H, Hayward JL, Klugman DJ, et al: Treatment of early breast cancer: A report after ten years of a clinical trial . Br Med J 1972;2:423-429.Crossref 6. Hayward JL: The Guy's trial of treatments of 'early breast cancer.' World J Surg 1977;1:314-316.Crossref 7. Hayward JL: The Guy's Hospital trials on breast conservation , in Harris JR, Hellman S, Silen W (eds): Conservative Management of Breast Cancer . Philadelphia, JB Lippincott, 1983, pp 77-90. 8. Fisher B, Bauer M, Margulese R, et al: Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer . N Engl J Med 1985;312:665-673.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

The Significance of Local Control in the Primary Treatment of Breast Cancer: Lucy Wortham James Clinical Research Award

Archives of Surgery , Volume 122 (11) – Nov 1, 1987

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1987.01400230030004
Publisher site
See Article on Publisher Site

Abstract

Abstract • Two sequential clinical trials were carried out to compare wide excision with radical mastectomy in patients with early breast cancer with clinically negative nodes. In the first study there was an increased incidence of local recurrence in patients who had wide excision, but distant recurrence and survival were unaltered. In the second study, the distant recurrence and survival rates were also significantly impaired. A new analysis showed that there were significantly more patients with T1 tumors in the second study than in the first. Comparison of treatments by T status indicates that radical mastectomy gives significantly better results in patients with T1 tumors. There is no difference between the results of the two treatments in patients with T2 tumors. We comment on the implications of these findings for conservation treatment of early breast cancer. (Arch Surg 1987;122:1244-1247) References 1. Mustakallio S: Conservative treatment of breast cancer . Clin Radiol 1972;23:110-116.Crossref 2. Crile G: Treatment of breast cancer by local excision . Am J Surg 1965;109:400-403.Crossref 3. Fleming J, Atkinson L: Carcinoma of the breast . Med J Aust 1961;181-287. 4. Dixon RA: Results of treatment of breast cancer in South-east England . Br J Cancer 1969;23:9-20.Crossref 5. Atkins H, Hayward JL, Klugman DJ, et al: Treatment of early breast cancer: A report after ten years of a clinical trial . Br Med J 1972;2:423-429.Crossref 6. Hayward JL: The Guy's trial of treatments of 'early breast cancer.' World J Surg 1977;1:314-316.Crossref 7. Hayward JL: The Guy's Hospital trials on breast conservation , in Harris JR, Hellman S, Silen W (eds): Conservative Management of Breast Cancer . Philadelphia, JB Lippincott, 1983, pp 77-90. 8. Fisher B, Bauer M, Margulese R, et al: Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer . N Engl J Med 1985;312:665-673.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Nov 1, 1987

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