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Elevation of immunoreactive CSF TRH in depressed patients

Elevation of immunoreactive CSF TRH in depressed patients The concentration of thyrotropin-releasing hormone (TRH), a tripeptide (pyroglutamylhistidylprolin-amide), in the CSF of drug-free patients with DSM-III major depression, somatization disorder, and peripheral neurological disorders was measured with a sensitive and specific radioimmunoassay. The depressed patients had markedly higher CSF TRH concentrations than the other patient groups, and this finding could not be attributed to any demographic variables. The elevation of TRH in CSF provides further evidence of hypothalamic-pituitary-thyroid dysfunction in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Psychiatry American Psychiatric Publishing, Inc (Journal)

Elevation of immunoreactive CSF TRH in depressed patients

American Journal of Psychiatry , Volume 145 (12): 1526 – Dec 1, 1988

Elevation of immunoreactive CSF TRH in depressed patients

American Journal of Psychiatry , Volume 145 (12): 1526 – Dec 1, 1988

Abstract

The concentration of thyrotropin-releasing hormone (TRH), a tripeptide (pyroglutamylhistidylprolin-amide), in the CSF of drug-free patients with DSM-III major depression, somatization disorder, and peripheral neurological disorders was measured with a sensitive and specific radioimmunoassay. The depressed patients had markedly higher CSF TRH concentrations than the other patient groups, and this finding could not be attributed to any demographic variables. The elevation of TRH in CSF provides further evidence of hypothalamic-pituitary-thyroid dysfunction in

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Publisher
American Psychiatric Publishing, Inc (Journal)
Copyright
Copyright © 1988 American Psychiatric Association. All rights reserved.
ISSN
0002-953X
Publisher site
See Article on Publisher Site

Abstract

The concentration of thyrotropin-releasing hormone (TRH), a tripeptide (pyroglutamylhistidylprolin-amide), in the CSF of drug-free patients with DSM-III major depression, somatization disorder, and peripheral neurological disorders was measured with a sensitive and specific radioimmunoassay. The depressed patients had markedly higher CSF TRH concentrations than the other patient groups, and this finding could not be attributed to any demographic variables. The elevation of TRH in CSF provides further evidence of hypothalamic-pituitary-thyroid dysfunction in

Journal

American Journal of PsychiatryAmerican Psychiatric Publishing, Inc (Journal)

Published: Dec 1, 1988

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