Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus

DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe... DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus Andrea Marzi 1 , 2 , † , Thomas Gramberg 1 , 2 , † , Graham Simmons 3 , † , Peggy Möller 4 , Andrew J. Rennekamp 3 , Mandy Krumbiegel 1 , 2 , Martina Geier 1 , 2 , Jutta Eisemann 5 , Nadine Turza 5 , Bertrand Saunier 6 , Alexander Steinkasserer 5 , Stephan Becker 4 , Paul Bates 3 , Heike Hofmann 1 , 2 , and Stefan Pöhlmann 1 , 2 , * 1 Institute for Clinical and Molecular Virology 2 Nikolaus-Fiebiger-Center 5 Department of Dermatology, University of Erlangen-Nürnberg, Erlangen 4 Institute for Virology, Philipps-University Marburg, Marburg, Germany 3 Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 6 Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, Athens, Ohio ABSTRACT The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Virology American Society For Microbiology

DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus

DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus

Journal of Virology , Volume 78 (21): 12090 – Nov 1, 2004

Abstract

DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus Andrea Marzi 1 , 2 , † , Thomas Gramberg 1 , 2 , † , Graham Simmons 3 , † , Peggy Möller 4 , Andrew J. Rennekamp 3 , Mandy Krumbiegel 1 , 2 , Martina Geier 1 , 2 , Jutta Eisemann 5 , Nadine Turza 5 , Bertrand Saunier 6 , Alexander Steinkasserer 5 , Stephan Becker 4 , Paul Bates 3 , Heike Hofmann 1 , 2 , and Stefan Pöhlmann 1 , 2 , * 1 Institute for Clinical and Molecular Virology 2 Nikolaus-Fiebiger-Center 5 Department of Dermatology, University of Erlangen-Nürnberg, Erlangen 4 Institute for Virology, Philipps-University Marburg, Marburg, Germany 3 Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 6 Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, Athens, Ohio ABSTRACT The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo.

Loading next page...
 
/lp/american-society-for-microbiology/dc-sign-and-dc-signr-interact-with-the-glycoprotein-of-marburg-virus-D3hTJ5By1j

References (66)

Publisher
American Society For Microbiology
Copyright
Copyright © 2004 by the American society for Microbiology.
ISSN
0022-538X
eISSN
1098-5514
DOI
10.1128/JVI.78.21.12090-12095.2004
pmid
15479853
Publisher site
See Article on Publisher Site

Abstract

DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus Andrea Marzi 1 , 2 , † , Thomas Gramberg 1 , 2 , † , Graham Simmons 3 , † , Peggy Möller 4 , Andrew J. Rennekamp 3 , Mandy Krumbiegel 1 , 2 , Martina Geier 1 , 2 , Jutta Eisemann 5 , Nadine Turza 5 , Bertrand Saunier 6 , Alexander Steinkasserer 5 , Stephan Becker 4 , Paul Bates 3 , Heike Hofmann 1 , 2 , and Stefan Pöhlmann 1 , 2 , * 1 Institute for Clinical and Molecular Virology 2 Nikolaus-Fiebiger-Center 5 Department of Dermatology, University of Erlangen-Nürnberg, Erlangen 4 Institute for Virology, Philipps-University Marburg, Marburg, Germany 3 Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 6 Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, Athens, Ohio ABSTRACT The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo.

Journal

Journal of VirologyAmerican Society For Microbiology

Published: Nov 1, 2004

There are no references for this article.