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Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae José L. Crespo and Michael N. Hall * Division of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland SUMMARY TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Microbiology and Molecular Biology Reviews American Society For Microbiology

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

Microbiology and Molecular Biology Reviews , Volume 66 (4): 579 – Dec 1, 2002

Abstract

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae José L. Crespo and Michael N. Hall * Division of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland SUMMARY TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.

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Publisher
American Society For Microbiology
Copyright
Copyright © 2002 by the American society for Microbiology.
ISSN
1092-2172
eISSN
1098-5557
DOI
10.1128/MMBR.66.4.579-591.2002
Publisher site
See Article on Publisher Site

Abstract

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae José L. Crespo and Michael N. Hall * Division of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland SUMMARY TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.

Journal

Microbiology and Molecular Biology ReviewsAmerican Society For Microbiology

Published: Dec 1, 2002

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