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Genome Sequence of a Novel HIV-1 Circulating Recombinant Form 54_01B from Malaysia

Genome Sequence of a Novel HIV-1 Circulating Recombinant Form 54_01B from Malaysia Free Genome Sequence of a Novel HIV-1 Circulating Recombinant Form 54_01B from Malaysia Kim Tien Ng a , Lai Yee Ong a , Yutaka Takebe a , b , Adeeba Kamarulzaman a and Kok Keng Tee a a Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia b AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan ABSTRACT We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B′ and CRF01_AE, with identical recombination breakpoints observed in the gag , pol , and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B′ and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Virology American Society For Microbiology

Genome Sequence of a Novel HIV-1 Circulating Recombinant Form 54_01B from Malaysia

Genome Sequence of a Novel HIV-1 Circulating Recombinant Form 54_01B from Malaysia

Journal of Virology , Volume 86 (20): 11405 – Oct 15, 2012

Abstract

Free Genome Sequence of a Novel HIV-1 Circulating Recombinant Form 54_01B from Malaysia Kim Tien Ng a , Lai Yee Ong a , Yutaka Takebe a , b , Adeeba Kamarulzaman a and Kok Keng Tee a a Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia b AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan ABSTRACT We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B′ and CRF01_AE, with identical recombination breakpoints observed in the gag , pol , and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B′ and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.

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References (8)

Publisher
American Society For Microbiology
Copyright
Copyright © 2012 by the American society for Microbiology.
ISSN
0022-538X
eISSN
1098-5514
DOI
10.1128/JVI.01949-12
pmid
22997423
Publisher site
See Article on Publisher Site

Abstract

Free Genome Sequence of a Novel HIV-1 Circulating Recombinant Form 54_01B from Malaysia Kim Tien Ng a , Lai Yee Ong a , Yutaka Takebe a , b , Adeeba Kamarulzaman a and Kok Keng Tee a a Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia b AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan ABSTRACT We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B′ and CRF01_AE, with identical recombination breakpoints observed in the gag , pol , and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B′ and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.

Journal

Journal of VirologyAmerican Society For Microbiology

Published: Oct 15, 2012

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