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A Life in Bacillus subtilis Signal Transduction

A Life in Bacillus subtilis Signal Transduction This is a tale of how technology drove the discovery of the molecular basis for signal transduction in the initiation of sporulation in Bacillus subtilis and in bacterial two-component systems. It progresses from genetics to cloning and sequencing to biochemistry to structural biology to an understanding of how proteins evolve interaction specificity and to identification of interaction surfaces by statistical physics. This is about how the people in my laboratory accomplished this feat; without them little would have been done. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

A Life in Bacillus subtilis Signal Transduction

Hoch, James A.
Annual Review of Microbiology , Volume 71: 19 – Sep 8, 2017
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Publisher
Annual Reviews
Copyright
Copyright 2017 by Annual Reviews. All rights reserved
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev-micro-030117-020355
pmid
28886686
Publisher site
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Abstract

This is a tale of how technology drove the discovery of the molecular basis for signal transduction in the initiation of sporulation in Bacillus subtilis and in bacterial two-component systems. It progresses from genetics to cloning and sequencing to biochemistry to structural biology to an understanding of how proteins evolve interaction specificity and to identification of interaction surfaces by statistical physics. This is about how the people in my laboratory accomplished this feat; without them little would have been done.

Journal

Annual Review of Microbiology – Annual Reviews

Published: Sep 8, 2017

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