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/lp/annual-reviews/a-life-of-adventure-in-immunobiology-aVh26q4Ud5
- Publisher
- Annual Reviews
- Copyright
- Copyright © 2010 by Annual Reviews. All rights reserved
- ISSN
- 0732-0582
- eISSN
- 1545-3278
- DOI
- 10.1146/annurev-immunol-030409-101248
- pmid
- 19968560
- Publisher site
- See Article on Publisher Site
Abstract
This article outlines my early start in medicine, a late start in immunology research, and my efforts to integrate the two activities. I first describe some of the background information, excitement, and implications of the recognition of T and B cells as separate but functionally intertwined arms of the adaptive immune system. The article continues with a brief account of my colleagues' and my efforts to use the model of hematopoietic stem cell differentiation along T and B cell lines to gain a better understanding of immunodeficiency diseases and lymphoid malignancies. It concludes with the discovery of a more ancient adaptive immune system in which T-like and B-like cells in jawless vertebrates use variable lymphocyte receptors constructed with leucine-rich-repeat sequences to recognize antigens.
Journal
Annual Review of Immunology – Annual Reviews
Published: Apr 23, 2009