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Analysis of the Expression and Function of Class-II Major Histocompatibility Complex-Encoded Molecules by DNA-Mediated Gene Transfer

Analysis of the Expression and Function of Class-II Major Histocompatibility Complex-Encoded... General The major histocompatibility complex (MHC) was first recognized when the genes were mapped that are responsible for acute tissue or tumor graft rejection between members of a species (1). This chromosomal region contains a large number of genes whose products play particularly important roles in the self-nonself discrimination processes of the immune 1 The US Government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. GERMAIN & MALISSEN system. Recent advances in both in vitro methods of cellular immunologic study and recombinant DNA technology have permitted an explosive increase in our knowledge of the structure of individual MHC genes and their products and of the overall organization of these genes within the MHC. Perhaps equally significant has been the application of DNA­ mediated gene transfer (DMGT) to the analysis of structure-function relationships of MHC-gene products. Use of DMGT promises to provide substantial new insight into the actual biochemical bases of immune recognition and regulation, processes highly dependent upon the fine structure of MHC-encoded gene products and the lymphocyte receptors with which they interact. This review focuses on recent work utilizing this approach to identify individual class-II MHC genes and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Analysis of the Expression and Function of Class-II Major Histocompatibility Complex-Encoded Molecules by DNA-Mediated Gene Transfer

Germain, R N; Malissen, B
Annual Review of Immunology , Volume 4 (1) – Apr 1, 1986
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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.04.040186.001433
pmid
3518745
Publisher site
See Article on Publisher Site

Abstract

General The major histocompatibility complex (MHC) was first recognized when the genes were mapped that are responsible for acute tissue or tumor graft rejection between members of a species (1). This chromosomal region contains a large number of genes whose products play particularly important roles in the self-nonself discrimination processes of the immune 1 The US Government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. GERMAIN & MALISSEN system. Recent advances in both in vitro methods of cellular immunologic study and recombinant DNA technology have permitted an explosive increase in our knowledge of the structure of individual MHC genes and their products and of the overall organization of these genes within the MHC. Perhaps equally significant has been the application of DNA­ mediated gene transfer (DMGT) to the analysis of structure-function relationships of MHC-gene products. Use of DMGT promises to provide substantial new insight into the actual biochemical bases of immune recognition and regulation, processes highly dependent upon the fine structure of MHC-encoded gene products and the lymphocyte receptors with which they interact. This review focuses on recent work utilizing this approach to identify individual class-II MHC genes and

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1986

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