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Antiarrhythmic Drugs: Electrophysiological and Pharmacokinetic Considerations

Antiarrhythmic Drugs: Electrophysiological and Pharmacokinetic Considerations This review of the disposition and e1ectrophysiological effects of antiarrhythmic drugs emphasizes literature published since 1970.2 We have restricted ourselves to a consideration of those drugs most widely used in the treatment of clinical arrhyth­ mias. Several important advances in cardiac electrophysiology and pharmacology have been made since the last review (1) which has furthered our understanding of the efficacy of these drugs. Progress continues to be made in our understanding of how the cardiac action potential is generated and propagated in the mammalian heart. Advances have been made both at the basic and clinical level in our under­ standing of the origin of cardiac arrhythmias. It is impossible to include a discussion of the ionic basis of the cardiac action potential and the electrophysiological basis for disturbances in cardiac rhythm in a review of limited length. The reader is referred to several recent reviews and monographs for these basic discussions (2-5). An area of active investigation has been the elucidation of the e1ectrophysiological properties of cells from diseased human hearts and canine hearts subjected to myocardial infarction. The electrophysiological effects of antiarrhythmic drugs on cells surviving infarction have only begun to be investigated, but already it is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Antiarrhythmic Drugs: Electrophysiological and Pharmacokinetic Considerations

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Publisher
Annual Reviews
Copyright
Copyright 1975 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.15.040175.001023
pmid
1096787
Publisher site
See Article on Publisher Site

Abstract

This review of the disposition and e1ectrophysiological effects of antiarrhythmic drugs emphasizes literature published since 1970.2 We have restricted ourselves to a consideration of those drugs most widely used in the treatment of clinical arrhyth­ mias. Several important advances in cardiac electrophysiology and pharmacology have been made since the last review (1) which has furthered our understanding of the efficacy of these drugs. Progress continues to be made in our understanding of how the cardiac action potential is generated and propagated in the mammalian heart. Advances have been made both at the basic and clinical level in our under­ standing of the origin of cardiac arrhythmias. It is impossible to include a discussion of the ionic basis of the cardiac action potential and the electrophysiological basis for disturbances in cardiac rhythm in a review of limited length. The reader is referred to several recent reviews and monographs for these basic discussions (2-5). An area of active investigation has been the elucidation of the e1ectrophysiological properties of cells from diseased human hearts and canine hearts subjected to myocardial infarction. The electrophysiological effects of antiarrhythmic drugs on cells surviving infarction have only begun to be investigated, but already it is

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1975

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