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Antibiotics

Antibiotics By JOHN HAYS BAILEY AND CHESTER J. CAVALLITO Sterling-Winthrop Research Institute, Rensselaer, New York The subject will be discussed under three general headings: the antibiotics per se, mode of action, and resistance development. The antibiotics will be discussed under their source, using an al­ phabetical rather than taxonomic order. Publications are disre­ garded that are abstracts of data or that present so little experi­ mental data that critical evaluation is impossible. ACTINOMYCES Most of the antibiotics produced by actinomyces have not been well characterized chemically and in only a few instances has the impulse to name the antibiotic substance been resisted. It may well be that at least some of the "new" antibiotics will be shown to be streptomycin or one of the other previously known substances. Trussell et at. (1) report the production of antibiotic activity in shaken cultures of an unidentified actinomyces. On the basis of antibacterial activity and mouse protection tests, the authors believe that at least two antibiotics are produced by this organism. One is probably streptomycin; the other, on the basis of toxicity, is thought to be streptothricin-like. Actidione, produced by a streptomycin-yielding strain of Streptomyces griseus, has been isolated and crystallized by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

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Publisher
Annual Reviews
Copyright
Copyright 1948 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.02.100148.001043
pmid
18104346
Publisher site
See Article on Publisher Site

Abstract

By JOHN HAYS BAILEY AND CHESTER J. CAVALLITO Sterling-Winthrop Research Institute, Rensselaer, New York The subject will be discussed under three general headings: the antibiotics per se, mode of action, and resistance development. The antibiotics will be discussed under their source, using an al­ phabetical rather than taxonomic order. Publications are disre­ garded that are abstracts of data or that present so little experi­ mental data that critical evaluation is impossible. ACTINOMYCES Most of the antibiotics produced by actinomyces have not been well characterized chemically and in only a few instances has the impulse to name the antibiotic substance been resisted. It may well be that at least some of the "new" antibiotics will be shown to be streptomycin or one of the other previously known substances. Trussell et at. (1) report the production of antibiotic activity in shaken cultures of an unidentified actinomyces. On the basis of antibacterial activity and mouse protection tests, the authors believe that at least two antibiotics are produced by this organism. One is probably streptomycin; the other, on the basis of toxicity, is thought to be streptothricin-like. Actidione, produced by a streptomycin-yielding strain of Streptomyces griseus, has been isolated and crystallized by

Journal

Annual Review of MicrobiologyAnnual Reviews

Published: Oct 1, 1948

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