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Antigen Presentation by Major Histocompatibility Complex Class I-B Molecules

Antigen Presentation by Major Histocompatibility Complex Class I-B Molecules Class I-b genes constitute the majority of MHC class I loci. These mono­ morphic or oligomorphic molecules have been described in many organisms; they are best characterized in the mouse, which contains a substantial number of potentially intact genes. Two main characteristics differentiate class I-b from class I-a molecules: limited polymorphism and lower cell surface expression. These distinguishing features suggest possible general­ izations regarding the evolution and function of this class. Additionally, class I-b proteins tend to have shorter cytoplasmic domains or in some cases may be secreted or may substitute a lipid anchor for the trans­ membrane domain. Some are also expressed in a limited distribution of cells or tissues. At least six mouse MHC class I-b molecules have been shown to present antigens to r:x.f3 or yfJ T cells. Recent advances have provided insight into the physiological function ofH-2M3" and have defined the natural peptide­ binding motif of Qa-2. In addition, significant progress has been made toward better understanding of other class I-b molecules, including Qa-l, TL, HLA-E, HLA-G, and the MHC-unlinked class I molecule CDl . We begin this review, however, by arguing that the dichotomous cate­ gorization of MHC genes as class I-a and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Antigen Presentation by Major Histocompatibility Complex Class I-B Molecules

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References (45)

Publisher
Annual Reviews
Copyright
Copyright 1994 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.12.040194.004203
pmid
8011299
Publisher site
See Article on Publisher Site

Abstract

Class I-b genes constitute the majority of MHC class I loci. These mono­ morphic or oligomorphic molecules have been described in many organisms; they are best characterized in the mouse, which contains a substantial number of potentially intact genes. Two main characteristics differentiate class I-b from class I-a molecules: limited polymorphism and lower cell surface expression. These distinguishing features suggest possible general­ izations regarding the evolution and function of this class. Additionally, class I-b proteins tend to have shorter cytoplasmic domains or in some cases may be secreted or may substitute a lipid anchor for the trans­ membrane domain. Some are also expressed in a limited distribution of cells or tissues. At least six mouse MHC class I-b molecules have been shown to present antigens to r:x.f3 or yfJ T cells. Recent advances have provided insight into the physiological function ofH-2M3" and have defined the natural peptide­ binding motif of Qa-2. In addition, significant progress has been made toward better understanding of other class I-b molecules, including Qa-l, TL, HLA-E, HLA-G, and the MHC-unlinked class I molecule CDl . We begin this review, however, by arguing that the dichotomous cate­ gorization of MHC genes as class I-a and

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1994

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