Antigen Presentation in the Autoimmune Diabetes of the NOD Mouse

Emil R. Unanue

doi:10.1146/annurev-immunol-032712-095941

Loading next page...

References (206)

Thomas Delong, R. Baker, Jing He, G. Barbour, B. Bradley, K. Haskins (2012)
Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A
Diabetes, 61
Seon-Kyeong Kim, K. Tarbell, M. Sanna, M. Vadeboncoeur, Tibor Warganich, Mark Lee, Mark Davis, H. Mcdevitt (2004)
Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells.
Proceedings of the National Academy of Sciences of the United States of America, 101 39
P. Vafiadis, S. Bennett, J. Todd, J. Nadeau, R. Grabs, C. Goodyer, Saman Wickramasinghe, E. Colle, C. Polychronakos (1997)
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Nature Genetics, 15
T. Miyazaki, M. Uno, M. Uehira, H. Kikutani, T. Kishimoto, M. Kimoto, H. Nishimoto, J. Miyazaki, K. Yamamura (1990)
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice
Nature, 345
Cassie Harrington, Angela Paez, Tim Hunkapiller, V. Mannikko, T. Brabb, MaryEllen Ahearn, Craig Beeson, Joan Goverman (1998)
Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein.
Immunity, 8 5
F. Wong, J. Karttunen, C. Dumont, L. Wen, I. Visintin, Ingrid Pilip, N. Shastri, E. Pamer, C. Janeway (1999)
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library
Nature Medicine, 5
G. Lennon, M. Bettini, A. Burton, Erica Vincent, P. Arnold, P. Santamaria, D. Vignali (2009)
T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event.
Immunity, 31 4
G. Bell, S. Horita, J. Karam (1984)
A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus
Diabetes, 33
A. Pugliese, M. Zeller, Alarico Fernandez, Laura Zalcberg, R. Bartlett, C. Ricordi, M. Pietropaolo, G. Eisenbarth, S. Bennett, D. Patel (1997)
The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
Nature Genetics, 15
J. Elliott, H. Qin, Siinita Bhatti, Dean Smith, R. Singh, T. Dillon, J. Lauzon, Bhagirath Singh (1994)
Immunization With the Larger Isoform of Mouse Glutamic Acid Decarboxylase (GAD67) Prevents Autoimmune Diabetes in NOD Mice
Diabetes, 43
B. Calderon, E. Unanue (2012)
Antigen presentation events in autoimmune diabetes.
Current opinion in immunology, 24 1
Thomas Delong, R. Baker, N. Reisdorph, R. Reisdorph, R. Powell, M. Armstrong, G. Barbour, B. Bradley, K. Haskins (2011)
Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4+ T Cells
Diabetes, 60
M. Crawford, D. Daniel, Dale Wegmann, H. Yang, Ronald Gill (1997)
Autoimmune islet damage mediated by insulin-specific T cells.
Transplantation proceedings, 29 1-2
M. Pietropaolo, M. Peakman, Susan Pietropaolo, M. Zanone, T. Foley, D. Becker, M. Trucco (1998)
Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus.
Journal of autoimmunity, 11 1
D. Hausmann, Bei Yu, S. Hausmann, K. Wucherpfennig (1999)
pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH
The Journal of Experimental Medicine, 189
I. Durinovic-Bello, B. Boehm, A. Ziegler (2002)
Predominantly recognized proinsulin T helper cell epitopes in individuals with and without islet cell autoimmunity.
Journal of autoimmunity, 18 1
B. Calderon, A. Suri, Mark Miller, E. Unanue (2008)
Dendritic cells in islets of Langerhans constitutively present β cell-derived peptides bound to their class II MHC molecules
Proceedings of the National Academy of Sciences, 105
Karine Thébault-Baumont, Danielle Dubois-Laforgue, P. Krief, J. Briand, P. Halbout, Karine Vallon-Geoffroy, J. Morin, V. Laloux, A. Lehuen, J. Carel, J. Jami, S. Muller, C. Boitard (2003)
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice.
The Journal of clinical investigation, 111 6
E. Carrasco-Marín, J. Shimizu, O. Kanagawa, E. Unanue (1996)
The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.
Journal of immunology, 156 2
P. Westermark, A. Andersson, G. Westermark (2011)
Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.
Physiological reviews, 91 3
C. Aspord, C. Thivolet (2002)
Nasal administration of CTB‐insulin induces active tolerance against autoimmune diabetes in non‐obese diabetic (NOD) mice
Clinical & Experimental Immunology, 130
Andrew Godkin, T. Friede, Miles Davenport, S. Stevanović, A. Willis, Derek Jewell, Adrian Hill, H. Rammensee (1997)
Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2).
International immunology, 9 6
A. Suri, J. Walters, O. Kanagawa, M. Gross, E. Unanue (2003)
Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition
Proceedings of the National Academy of Sciences of the United States of America, 100
Jide Tian, M. Atkinson, M. Clare-Salzler, A. Herschenfeld, T. Forsthuber, P. Lehmann, D. Kaufman (1996)
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
The Journal of Experimental Medicine, 183
A. Renold, J. Steinke, J. Soeldner, H. Antoniades, R. Smith (1966)
Immunological response to the prolonged administration of heterologous and homologous insulin in cattle.
The Journal of clinical investigation, 45 5
S. Torii (2009)
Expression and function of IA-2 family proteins, unique neuroendocrine-specific protein-tyrosine phosphatases.
Endocrine journal, 56 5
K. Kelemen, M. Crawford, R. Gill, J. Hutton, D. Wegmann (1999)
Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants.
Diabetes, 48 8
Sheena Pinto, Chloé Michel, Hannah Schmidt-Glenewinkel, N. Harder, K. Rohr, S. Wild, B. Brors, B. Kyewski (2013)
Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity
Proceedings of the National Academy of Sciences, 110
Brian Stadinski, Li Zhang, F. Crawford, P. Marrack, G. Eisenbarth, J. Kappler (2010)
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register
Proceedings of the National Academy of Sciences, 107
A. Kubosaki, J. Miura, A. Notkins (2003)
IA-2 is not required for the development of diabetes in NOD mice
Diabetologia, 47
T. Hoorn, P. Paul, M. Jongsma, J. Neefjes (2011)
Routes to manipulate MHC class II antigen presentation.
Current opinion in immunology, 23 1
C. Chao, H. Mcdevitt (1997)
Identification of immunogenic epitopes of GAD 65 presented by A g7 in non-obese diabetic mice
Immunogenetics, 46
P. Arnold, A. Burton, D. Vignali (2004)
Diabetes Incidence Is Unaltered in Glutamate Decarboxylase 65-Specific TCR Retrogenic Nonobese Diabetic Mice: Generation by Retroviral-Mediated Stem Cell Gene Transfer1
The Journal of Immunology, 173
J. Jasinski, Liping Yu, M. Nakayama, Marcella Li, M. Lipes, G. Eisenbarth, E. Liu (2006)
Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2g7 Homozygosity, and Insulin 2 Gene Knockout
Diabetes, 55
D. Wegmann, Mary Norbury‐Glaseru, Dylan Danielf (1994)
Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice
European Journal of Immunology, 24
D. Daniel, R. Gill, N. Schloot, D. Wegmann (1995)
Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice
European Journal of Immunology, 25
B. Miller, M. Appel, J. O'neil, L. Wicker (1988)
Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.
Journal of immunology, 140 1
E. Husebye, Mark Anderson (2010)
Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis.
Immunity, 32 4
Alison Every, D. Kramer, S. Mannering, A. Lew, L. Harrison (2006)
Intranasal Vaccination with Proinsulin DNA Induces Regulatory CD4+ T Cells That Prevent Experimental Autoimmune Diabetes1
The Journal of Immunology, 176
M. Levisetti, Danna Lewis, A. Suri, E. Unanue (2008)
Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice
Diabetes, 57
John Kim, W. Richter, H. Aanstoot, Yuguang Shi, Qin Fu, R. Rajotte, G. Warnock, S. Baekkeskov (1993)
Differential Expression of GAD65 and GAD67 in Human, Rat, and Mouse Pancreatic Islets
Diabetes, 42
R. Quartey‐Papafio, T. Lund, P. Chandler, J. Picard, P. Ozegbe, S. Day, P. Hutchings, L. O’Reilly, D. Kioussis, E. Simpson (1995)
Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus.
Journal of immunology, 154 10
J. Lee, G. Grodsky, J. Caplan, L. Craw (1969)
Experimental immune diabetes in the rabbit. Light, fluorescence, and electron microscopic studies.
The American journal of pathology, 57 3
D. Alleva, P. Crowe, Li-Qin Jin, W. Kwok, N. Ling, M. Gottschalk, P. Conlon, P. Gottlieb, A. Putnam, A. Gaur (2001)
A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin.
The Journal of clinical investigation, 107 2
L. Klein, M. Hinterberger, Gerald Wirnsberger, B. Kyewski (2009)
Antigen presentation in the thymus for positive selection and central tolerance induction
Nature Reviews Immunology, 9
A. Suri, J. Shimizu, J. Katz, S. Sakaguchi, E. Unanue, O. Kanagawa (2004)
Regulation of autoimmune diabetes by non‐islet‐specific T cells — a role for the glucocorticoid‐induced TNF receptor
European Journal of Immunology, 34
W. Gurr, M. Shaw, Yanxia Li, R. Sherwin (2007)
RegII Is a β-Cell Protein and Autoantigen in Diabetes of NOD Mice
Diabetes, 56
L. Banaei-Bouchareb, V. Gouon-Evans, D. Samara-Boustani, Marie Castellotti, P. Czernichow, J. Pollard, M. Polak (2004)
Insulin cell mass is altered in Csf1op/Csf1op macrophage‐deficient mice
Journal of Leukocyte Biology, 76
A. Renold, S. Soeldner, J. Steinke (2008)
Immunological Studies with Homologous and Heterologous Pancreatic Insulin in the Cow
J. Shimizu, E. Carrasco-Marín, O. Kanagawa, E. Unanue (1995)
Relationship between beta cell injury and antigen presentation in NOD mice.
Journal of immunology, 155 8
R. Latek, A. Suri, S. Petzold, C. Nelson, O. Kanagawa, E. Unanue, D. Fremont (2000)
Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice.
Immunity, 12 6
B. Reizis, D. Altmann, I. Cohen (1997)
Biochemical characterization of the human diabetes‐associated HLA‐DQ8 allelic product: Similarity to the major histocompatibility complex class II I‐Ag7 protein of non‐obese diabetic mice
European Journal of Immunology, 27
P. Wright, R. Gingerich, S. King, P. Lacy (1976)
Pancreatic lesions induced in rabbits and guinea-pigs with pancreatic antigens.
Clinical and experimental immunology, 25 2
Valeria Judkowski, C. Pinilla, K. Schroder, L. Tucker, N. Sarvetnick, Darcy Wilson (2001)
Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice1
The Journal of Immunology, 166
Jens Derbinski, Jana Gäbler, B. Brors, S. Tierling, S. Jonnakuty, M. Hergenhahn, L. Peltonen, J. Walter, B. Kyewski (2005)
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
The Journal of Experimental Medicine, 202
J. Todd, J. Bell, H. Mcdevitt (1987)
HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
Nature, 329
M. Frikke, R. Gingerich, P. Stranahan, G. Carter, A. Bauman, M. Greider, P. Wright, P. Lacy (1974)
Distribution of injected insulin and insulin-antibody complexes in normal and insulin-immunized animals
Diabetologia, 10
N. Schloot, D. Daniel, M. Norbury-Glaser, D. Wegmann (1996)
Peripheral T cell clones from NOD mice specific for GAD65 peptides: lack of islet responsiveness or diabetogenicity.
Journal of autoimmunity, 9 3
J. Peterson, B. Pike, M. Mcduffie, K. Haskins (1994)
Islet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice.
Journal of immunology, 153 6
V. Ablamunits, D. Elias, Irun Cohen (1999)
The pathogenicity of islet‐infiltrating lymphocytes in the non‐obese diabetic (NOD) mouse
Clinical & Experimental Immunology, 115
E. Kawasaki, Kan Nakamura, G. Kuriya, T. Satoh, H. Kuwahara, Masakazu Kobayashi, N. Abiru, H. Yamasaki, K. Eguchi (2010)
Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes.
The Journal of clinical endocrinology and metabolism, 95 2
James Mohan, B. Calderon, Mark Anderson, E. Unanue (2013)
Pathogenic CD4+ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes
The Journal of Experimental Medicine, 210
Kon-Ho Lee, K. Wucherpfennig, D. Wiley (2001)
Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes
Nature Immunology, 2
C. Polychronakos, Quan Li (2011)
Understanding type 1 diabetes through genetics: advances and prospects
Nature Reviews Genetics, 12
A. Bankovich, A. Girvin, Achim Moesta, K. Garcia (2004)
Peptide register shifting within the MHC groove: theory becomes reality.
Molecular immunology, 40 14-15
Jens Derbinski, Antje Schulte, B. Kyewski, L. Klein (2001)
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
Nature Immunology, 2
K. Haskins (2005)
Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse.
Advances in immunology, 87
Y. Kanazawa, A. Shimada, Y. Oikawa, Y. Okubo, Ai Tada, Takatoshi Imai, J. Miyazaki, H. Itoh (2009)
Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes.
Journal of autoimmunity, 32 2
Kuan Chang, A. Suri, E. Unanue (2007)
Predicting peptides bound to I‐Ag7 class II histocompatibility molecules using a novel expectation‐maximization alignment algorithm
PROTEOMICS, 7
P. Achenbach, K. Kelemen, D. Wegmann, J. Hutton (2002)
Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice.
Journal of autoimmunity, 19 3
A. Kubosaki, Steffen Gross, J. Miura, K. Saeki, Min Zhu, Shin'ichiro Nakamura, W. Hendriks, A. Notkins (2004)
Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.
Diabetes, 53 7
V. Heath, P. Hutchings, D. Fowell, A. Cooke, D. Mason (1999)
Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes.
Diabetes, 48 11
S. Baekkeskov, H. Aanstoot, Stephan Christgai, Annette Reetz, M. Solimena, M. Cascalho, F. Folli, H. Richter-Olesen, P. Camilli (1990)
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
Nature, 347
R. Chicz, William Lane, R. Robinson, M. Trucco, J. Strominger, J. Gorga (1994)
Self-peptides bound to the type I diabetes associated class II MHC molecules HLA-DQ1 and HLA-DQ8.
International immunology, 6 11
James Mohan, M. Levisetti, B. Calderon, J. Herzog, S. Petzold, E. Unanue (2010)
Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes
Nature Immunology, 11
B. McFarland, A. Sant, T. Lybrand, C. Beeson (1999)
Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers.
Biochemistry, 38 50
P. Rotwein, S. Yokoyama, D. Didier, J. Chirgwin (1986)
Genetic analysis of the hypervariable region flanking the human insulin gene.
American journal of human genetics, 39 3
James Mohan, E. Unanue (2012)
Unconventional recognition of peptides by T cells and the implications for autoimmunity
Nature Reviews Immunology, 12
S. You, C. Chen, Wen-Hui Lee, Chun-Hua Wu, Valeria Judkowski, C. Pinilla, Darcy Wilson, Chih-pin Liu (2003)
Detection and Characterization of T Cells Specific for BDC2.5 T Cell-Stimulating Peptides1
The Journal of Immunology, 170
S. Lieberman, A. Evans, Bingye Han, Toshiyuki Takaki, Yuliya Vinnitskaya, J. Caldwell, D. Serreze, J. Shabanowitz, D. Hunt, S. Nathenson, P. Santamaria, T. DiLorenzo (2003)
Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
Proceedings of the National Academy of Sciences of the United States of America, 100
M. French, J. Allison, D. Cram, H. Thomas, M. Dempsey-Collier, Anabel Silva, H. Georgiou, T. Kay, L. Harrison, A. Lew (1997)
Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice
Diabetes, 46
P. Naquet, J. Ellis, D. Tibensky, A. Kenshole, Baghirath Singh, R. Hodges, T. Delovitch (1988)
T cell autoreactivity to insulin in diabetic and related non-diabetic individuals.
Journal of immunology, 140 8
S. Christianson, L. Shultz, E. Leiter (1993)
Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors
Diabetes, 42
K. Haskins, M. Portas, B. Bradley, D. Wegmann, K. Lafferty (1988)
T-Lymphocyte Clone Specific for Pancreatic Islet Antigen
Diabetes, 37
W. Toreson, J. Lee, G. Grodsky (1968)
The histopathology of immune diabetes in the rabbit.
The American journal of pathology, 52 5
T. Ellis, E. Jodoin, E. Ottendorfer, P. Salisbury, J. She, D. Schatz, M. Atkinson (1999)
Cellular immune responses against proinsulin: no evidence for enhanced reactivity in individuals with IDDM.
Diabetes, 48 2
G. Klöppel, E. Altenähr, G. Freytag, F. Jansen (2004)
Immune insulitis and manifest diabetes mellitus
Virchows Archiv A, 364
G. Semana, R. Gausling, R. Jackson, D. Hafler (1999)
T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects.
Journal of autoimmunity, 12 4
H. Kikutani, S. Makino (1992)
The murine autoimmune diabetes model: NOD and related strains.
Advances in immunology, 51
R. Steptoe, J. Ritchie, L. Harrison (2003)
Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes.
The Journal of clinical investigation, 111 9
J. Noble, H. Erlich (2012)
Genetics of type 1 diabetes.
Cold Spring Harbor perspectives in medicine, 2 1
M. Nakayama, N. Abiru, H. Moriyama, N. Babaya, E. Liu, D. Miao, Liping Yu, D. Wegmann, J. Hutton, J. Elliott, G. Eisenbarth (2005)
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
Nature, 435
H. Erlich, A. Valdes, J. Noble, J. Carlson, M. Varney, P. Concannon, J. Mychaleckyj, J. Todd, Persia Bonella, Anna Fear, E. Lavant, Anthony Louey, P. Moonsamy (2008)
HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk
Diabetes, 57
Masakazu Hattori, John Buse, Richard Jackson, Laurie Glimcher, Martin Dorf, M. Minami, S. Makino, K. Moriwaki, Hideshi Kuzuya, Hiroo Imura, W. Strauss, Jonathan Seidman, G. Eisenbarth (1986)
The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex.
Science, 231 4739
Katalin Kelemen, Dale Wegmann, John Hutton (2001)
T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse.
Diabetes, 50 8
Cécile Julier, B. Akolkar, Patrick Concannon, Grant Morahan, Concepcion Nierras, Alberto Pugliese (2009)
The Type I Diabetes Genetics Consortium ‘Rapid Response’ family-based candidate gene study: strategy, genes selection, and main outcome
Genes and Immunity, 10
A. Muir, AmmonPeck, M. Clare-Salzler, Yao-hua Song, Janet Comelius, Roberto, Luchetta, J. Krischer, N. Maclaren (1995)
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.
The Journal of clinical investigation, 95 2
F. Wong, A. Moustakas, L. Wen, G. Papadopoulos, C. Janeway (2002)
Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2Kd that stimulates CD8 T cells in insulin-dependent diabetes mellitus
Proceedings of the National Academy of Sciences of the United States of America, 99
A. Burton, Erica Vincent, P. Arnold, G. Lennon, M. Smeltzer, Chin-Shang Li, K. Haskins, J. Hutton, R. Tisch, E. Sercarz, P. Santamaria, C. Workman, D. Vignali (2008)
On the Pathogenicity of Autoantigen-Specific T-Cell Receptors
Diabetes, 57
N. Yin, Jiangnan Xu, F. Ginhoux, G. Randolph, M. Merad, Yaozhong Ding, J. Bromberg (2012)
Functional Specialization of Islet Dendritic Cell Subsets
The Journal of Immunology, 188
A. Chentoufi, C. Polychronakos (2002)
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes.
Diabetes, 51 5
S. Bennett, A. Lucassen, S. Gough, E. Powell, D. Undlien, L. Pritchard, M. Merriman, Y. Kawaguchi, M. Dronsfield, F. Pociot, J. Nerup, N. Bouzekri, A. Cambon-Thomsen, K. Rønningen, A. Barnett, S. Bain, J. Todd (1995)
Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
Nature Genetics, 9
V. Heath, N. Moore, S. Parnell, D. Mason (1998)
Intrathymic expression of genes involved in organ specific autoimmune disease.
Journal of autoimmunity, 11 4
P. Lacy, P. Wright (1965)
Allergic Interstitial Pancreatitis in Rats Injected with Guinea Pig Anti-insulin Serum
Diabetes, 14
J. Neefjes, M. Jongsma, P. Paul, O. Bakke (2011)
Towards a systems understanding of MHC class I and MHC class II antigen presentation
Nature Reviews Immunology, 11
E. Melanitou, D. Devendra, E. Liu, D. Miao, G. Eisenbarth (2004)
Early and Quantal (by Litter) Expression of Insulin Autoantibodies in the Nonobese Diabetic Mice Predict Early Diabetes Onset1
The Journal of Immunology, 173
D. Alleva, A. Gaur, Li-Qin Jin, D. Wegmann, P. Gottlieb, A. Pahuja, Eric Johnson, T. Motheral, A. Putnam, P. Crowe, N. Ling, S. Boehme, P. Conlon (2002)
Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide.
Diabetes, 51 7
Zhaohui Gong, Yongfeng Jin, Yaozhou Zhang (2007)
Suppression of diabetes in non-obese diabetic (NOD) mice by oral administration of a cholera toxin B subunit-insulin B chain fusion protein vaccine produced in silkworm.
Vaccine, 25 8
Dale Wegmann, G. Eisenbarth (2000)
It's insulin.
Journal of autoimmunity, 15 3
M. Zechel, J. Elliott, M. Atkinson, B. Singh (1998)
Characterization of novel T-cell epitopes on 65 kDa and 67 kDa glutamic acid decarboxylase relevant in autoimmune responses in NOD mice.
Journal of autoimmunity, 11 1
Jide Tian, Michael Clere-Salzler, A. Herschenfeld, Blake Middleton, D. Newman, R. Mueller, S. Arita, C. Evans, M. Atkinson, Y. Mullen, N. Sarvetnick, A. Tobin, P. Lehmann, D. Kaufman (1996)
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice
Nature Medicine, 2
D. Kaufman, M. Clare-Salzler, Jide Tian, T. Forsthuber, G. Ting, P. Robinson, M. Atkinson, E. Sercarz, A. Tobin, P. Lehmann (1993)
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
Nature, 366
Y. Dai, K. Jensen, A. Lehuen, E. Masteller, J. Bluestone, Darcy Wilson, E. Sercarz (2005)
A Peptide of Glutamic Acid Decarboxylase 65 Can Recruit and Expand a Diabetogenic T Cell Clone, BDC2.5, in the Pancreas1
The Journal of Immunology, 175
A. Ziegler, M. Rewers, O. Simell, T. Simell, J. Lempainen, A. Steck, C. Winkler, J. Ilonen, R. Veijola, M. Knip, E. Bonifacio, G. Eisenbarth (2013)
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.
JAMA, 309 23
H. Moriyama, N. Abiru, J. Paronen, K. Sikora, E. Liu, D. Miao, D. Devendra, J. Beilke, R. Gianani, R. Gill, G. Eisenbarth (2003)
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse
Proceedings of the National Academy of Sciences of the United States of America, 100
A. Suri, I. Vidavsky, K. Drift, O. Kanagawa, M. Gross, E. Unanue (2002)
In APCs, the Autologous Peptides Selected by the Diabetogenic I-Ag7 Molecule Are Unique and Determined by the Amino Acid Changes in the P9 Pocket1
The Journal of Immunology, 168
T. Stratmann, V. Apostolopoulos, V. Mallet-Désigné, A. Corper, C. Scott, I. Wilson, Angray Kang, L. Teyton (2000)
The I-Ag7 MHC Class II Molecule Linked to Murine Diabetes Is a Promiscuous Peptide Binder1
The Journal of Immunology, 165
E. Jaeckel, M. Lipes, H. Boehmer (2004)
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
Nature Immunology, 5
H. Acha-Orbea, H. Mcdevitt (1987)
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.
Proceedings of the National Academy of Sciences of the United States of America, 84 8
C. Daniel, B. Weigmann, R. Bronson, H. Boehmer (2011)
Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope
The Journal of Experimental Medicine, 208
G. Fousteri, J. Jasinski, Amy Dave, M. Nakayama, Philippe Pagni, F. Lambolez, T. Juntti, G. Sarikonda, Yang Cheng, M. Croft, H. Cheroutre, G. Eisenbarth, M. Herrath (2012)
Following the Fate of One Insulin-Reactive CD4 T cell
Diabetes, 61
K. Haskins, M. Portas, B. Bergman, K. Lafferty, B. Bradley (1989)
Pancreatic islet-specific T-cell clones from nonobese diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America, 86 20
V. Brezar, J. Carel, C. Boitard, R. Mallone (2011)
Beyond the hormone: insulin as an autoimmune target in type 1 diabetes.
Endocrine reviews, 32 5
D. Wegmann, Ronald Gill, Mary Glaser, N. Schloot, D. Daniel (1994)
Analysis of the spontaneous T cell response to insulin in NOD mice.
Journal of autoimmunity, 7 6
A. Lucassen, G. Screaton, C. Julier, Tim Elliott, M. Lathrop, J. Bell (1995)
Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype.
Human molecular genetics, 4 4
R. Tisch, Xiaodong Yang, R. Liblau, H. Mcdevitt (1994)
Administering glutamic acid decarboxylase to NOD mice prevents diabetes.
Journal of autoimmunity, 7 6
P. Wright (1961)
The production of experimental diabetes by means of insulin antibodies.
The American journal of medicine, 31
M. Puertas, J. Carrillo, X. Pastor, R. Ampudia, R. Planas, A. Alba, R. Bruno, R. Pujol-Borrell, J. Estanyol, M. Vives-Pi, J. Verdaguer (2007)
Peripherin Is a Relevant Neuroendocrine Autoantigen Recognized by Islet-Infiltrating B Lymphocytes1
The Journal of Immunology, 178
T. Wynn, A. Chawla, J. Pollard (2013)
Macrophage biology in development, homeostasis and disease
Nature, 496
M. Nussenzweig, F. Ginhoux, Kang Liu, J. Helft, M. Bogunovic, M. Greter, D. Hashimoto, J. Price, N. Yin, J. Bromberg, S. Lira, E. Stanley, Michel Nussenzweig, M. Merad (2009)
The origin and development of nonlymphoid tissue CD103+ DCs
The Journal of Experimental Medicine, 206
A. Corper, T. Stratmann, V. Apostolopoulos, C. Scott, K. Garcia, Angray Kang, I. Wilson, L. Teyton (2000)
A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.
Science, 288 5465
M. Levisetti, A. Suri, K. Frederick, E. Unanue (2004)
Absence of lymph nodes in NOD mice treated with lymphotoxin-beta receptor immunoglobulin protects from diabetes.
Diabetes, 53 12
B. Barratt, F. Payne, C. Lowe, R. Hermann, B. Healy, D. Harold, P. Concannon, N. Gharani, M. McCarthy, M. Olavesen, R. McCormack, C. Guja, C. Ionescu-Tîrgoviste, D. Undlien, K. Rønningen, K. Gillespie, E. Tuomilehto-Wolf, J. Tuomilehto, S. Bennett, D. Clayton, H. Cordell, J. Todd (2004)
Remapping the insulin gene/IDDM2 locus in type 1 diabetes.
Diabetes, 53 7
G. Morahan, M. Mehta, I. James, Wei-Min Chen, B. Akolkar, H. Erlich, J. Hilner, C. Julier, J. Nerup, C. Nierras, F. Pociot, J. Todd, S. Rich (2011)
Tests for Genetic Interactions in Type 1 Diabetes
Diabetes, 60
K. Tarbell, Mark Lee, E. Ranheim, C. Chao, M. Sanna, Seon-Kyeong Kim, P. Dickie, L. Teyton, Mark Davis, H. Mcdevitt (2002)
CD4+ T Cells from Glutamic Acid Decarboxylase (GAD)65-specific T Cell Receptor Transgenic Mice Are Not Diabetogenic and Can Delay Diabetes Transfer
The Journal of Experimental Medicine, 196
Wei Chen, I. Bergerot, J. Elliott, L. Harrison, N. Abiru, G. Eisenbarth, T. Delovitch (2001)
Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes1
The Journal of Immunology, 167
C. Byersdorfer, G. Schweitzer, E. Unanue (2005)
Diabetes Is Predicted by the β Cell Level of Autoantigen1
The Journal of Immunology, 175
James Mohan, S. Petzold, E. Unanue (2011)
Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion
The Journal of Experimental Medicine, 208
C. Verge, R. Gianani, E. Kawasaki, Liping Yu, M. Pietropaolo, H. Chase, G. Eisenbarth, R. Jackson (1996)
Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies
Diabetes, 45
A. Lucassen, C. Julier, J. Beressi, C. Boitard, P. Froguel, M. Lathrop, J. Bell (1993)
Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR
Nature Genetics, 4
A. Miyazaki, T. Hanafusa, K. Yamada, J. Miyagawa, H. Fujino-Kurihara, H. Nakajima, K. Nonaka, S. Tarui (1985)
Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study.
Clinical and experimental immunology, 60 3
Darcy Wilson (2003)
GAD-about BDC2.5: peptides that stimulate BDC2.5 T cells and inhibit IDDM.
Journal of autoimmunity, 20 3
N. Babaya, M. Nakayama, H. Moriyama, R. Gianani, T. Still, D. Miao, L. Yu, J. Hutton, G. Eisenbarth (2006)
A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2
Diabetologia, 49
Kuan Chang, E. Unanue (2009)
Prediction of HLA-DQ8 β cell peptidome using a computational program and its relationship to autoreactive T cells
International Immunology, 21
Li Zhang, M. Nakayama, G. Eisenbarth (2008)
Insulin as an autoantigen in NOD/human diabetes.
Current opinion in immunology, 20 1
Wesley Gregor, Julio Martin, J. Williamson, P. Lacy, D. Kipnis (1963)
A Study of the Diabetic Syndrome Produced in Rats by Anti-insulin Serum
Diabetes, 12
A. Suri, J. Walters, M. Gross, E. Unanue (2005)
Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity.
The Journal of clinical investigation, 115 8
S. Makino, Kikuko Kunimoto, Y. Muraoka, Y. Mizushima, Ken Katagiri, Y. Tochino (1980)
Breeding of a non-obese, diabetic strain of mice.
Jikken dobutsu. Experimental animals, 29 1
M. Levisetti, A. Suri, S. Petzold, E. Unanue (2007)
The Insulin-Specific T Cells of Nonobese Diabetic Mice Recognize a Weak MHC-Binding Segment in More Than One Form1
The Journal of Immunology, 178
J. Robertson, P. Jensen, B. Evavold (2000)
DO11.10 and OT-II T Cells Recognize a C-Terminal Ovalbumin 323–339 Epitope1
The Journal of Immunology, 164
F. Crawford, Brian Stadinski, Niyun Jin, A. Michels, M. Nakayama, P. Pratt, P. Marrack, G. Eisenbarth, J. Kappler (2011)
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
Proceedings of the National Academy of Sciences, 108
E. Nikoopour, C. Sandrock, K. Huszarik, O. Krougly, E. Lee‐Chan, E. Masteller, J. Bluestone, Bhagirath Singh (2011)
Cutting Edge: Vasostatin-1–Derived Peptide ChgA29–42 Is an Antigenic Epitope of Diabetogenic BDC2.5 T Cells in Nonobese Diabetic Mice
The Journal of Immunology, 186
K. Haskins, M. Mcduffie (1990)
Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone.
Science, 249 4975
W. Du, F. Wong, Ming Li, Jian Peng, Hao Qi, R. Flavell, R. Sherwin, L. Wen (2006)
TGF-β signaling is required for the function of insulin-reactive T regulatory cells
Journal of Clinical Investigation, 116
Kathleen Smith, D. Olson, R. Hirose, D. Hanahan (1997)
Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance.
International immunology, 9 9
R. Tisch, Bo Wang, D. Serreze (1999)
Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent.
Journal of immunology, 163 3
R. Baker, Thomas Delong, G. Barbour, B. Bradley, M. Nakayama, K. Haskins (2013)
Cutting Edge: CD4 T Cells Reactive to an Islet Amyloid Polypeptide Peptide Accumulate in the Pancreas and Contribute to Disease Pathogenesis in Nonobese Diabetic Mice
The Journal of Immunology, 191
M. Levisetti, A. Suri, I. Vidavsky, M. Gross, O. Kanagawa, E. Unanue (2003)
Autoantibodies and CD4 T cells target a beta cell retroviral envelope protein in non-obese diabetic mice.
International immunology, 15 12
N. Abiru, A. Maniatis, Liping Yu, D. Miao, H. Moriyama, D. Wegmann, G. Eisenbarth (2001)
Peptide and major histocompatibility complex-specific breaking of humoral tolerance to native insulin with the B9-23 peptide in diabetes-prone and normal mice.
Diabetes, 50 6
Béatrice Faideau, J. Briand, C. Lotton, I. Tardivel, P. Halbout, J. Jami, J. Elliott, P. Krief, S. Muller, C. Boitard, J. Carel (2004)
Expression of Preproinsulin-2 Gene Shapes the Immune Response to Preproinsulin in Normal Mice1
The Journal of Immunology, 172
R. Tisch, Xiao-Dong Yang, S. Singer, R. Liblau, L. Fugger, H. Mcdevitt (1993)
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
Nature, 366
M. Nakayama, J. Beilke, J. Jasinski, Masakazu Kobayashi, D. Miao, Marcella Li, M. Coulombe, E. Liu, J. Elliott, R. Gill, G. Eisenbarth (2007)
Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.
The Journal of clinical investigation, 117 7
C. Chao, H. Sytwu, E. Chen, Jon Toma, H. Mcdevitt (1999)
The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire.
Proceedings of the National Academy of Sciences of the United States of America, 96 16
M. Pietropaolo, R. Towns, G. Eisenbarth (2012)
Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes.
Cold Spring Harbor perspectives in medicine, 2 10
C. Scott, P. Peterson, L. Teyton, I. Wilson (1998)
Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues.
Immunity, 8 3
B. Reizis, M. Eisenstein, J. Bocková, S. Könen-Waisman, F. Mor, D. Elias, I. Cohen (1997)
Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7.
International immunology, 9 1
Yong Fan, W. Rudert, M. Grupillo, Jing He, G. Sisino, M. Trucco (2009)
Thymus‐specific deletion of insulin induces autoimmune diabetes
The EMBO Journal, 28
P. Qu, R. Ji, S. Kato (2003)
Histochemical analysis of lymphatic endothelial cells in the pancreas of non‐obese diabetic mice
Journal of Anatomy, 203
A. Bot, Dan Smith, S. Bot, A. Hughes, T. Wolfe, Lilin Wang, C. Woods, M. Herrath (2001)
Plasmid Vaccination with Insulin B Chain Prevents Autoimmune Diabetes in Nonobese Diabetic Mice1
The Journal of Immunology, 167
D. Zekzer, F. Wong, L. Wen, M. Altieri, T. Gurlo, H. Grafenstein, R. Sherwin (1997)
Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse
Diabetes, 46
Brian Stadinski, Thomas Delong, N. Reisdorph, R. Reisdorph, R. Powell, M. Armstrong, J. Piganelli, G. Barbour, B. Bradley, F. Crawford, P. Marrack, S. Mahata, J. Kappler, K. Haskins (2010)
Chromogranin A is an autoantigen in type 1 diabetes
Nature Immunology, 11
M. Nakayama, N. Babaya, D. Miao, K. Sikora, J. Elliott, G. Eisenbarth (2005)
Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout.
Journal of autoimmunity, 25 3
Bei Yu, L. Gauthier, D. Hausmann, K. Wucherpfennig (2000)
Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes
European Journal of Immunology, 30
E. Jaeckel, L. Klein, N. Martín‐Orozco, H. Boehmer (2003)
Normal Incidence of Diabetes in NOD Mice Tolerant to Glutamic Acid Decarboxylase
The Journal of Experimental Medicine, 197
R. Tisch, Bo Wang, M. Atkinson, D. Serreze, Randall Friedline (2001)
A Glutamic Acid Decarboxylase 65-Specific Th2 Cell Clone Immunoregulates Autoimmune Diabetes in Nonobese Diabetic Mice1
The Journal of Immunology, 166
Yi Wang, L. Hao, R. Gill, K. Lafferty (1987)
Autoimmune Diabetes in NOD Mouse Is L3T4 T-Lymphocyte Dependent
Diabetes, 36
B. Calderon, Javier Carrero, Mark Miller, E. Unanue (2011)
Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response
Proceedings of the National Academy of Sciences, 108
D. Zekzer, F. Wong, O. Ayalon, I. Millet, M. Altieri, S. Shintani, M. Solimena, R. Sherwin (1998)
GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.
The Journal of clinical investigation, 101 1
M. Brimnes, T. Jensen, T. Jorgensen, B. Michelsen, J. Troelsen, O. Werdelin (2002)
Low expression of insulin in the thymus of non-obese diabetic mice.
Journal of autoimmunity, 19 4
M. Gagnerault, J. Luan, C. Lotton, F. Lepault (2002)
Pancreatic Lymph Nodes Are Required for Priming of β Cell Reactive T Cells in NOD Mice
The Journal of Experimental Medicine, 196
W. Gurr, R. Yavari, L. Wen, M. Shaw, C. Mora, L. Christa, R. Sherwin (2002)
A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice.
Diabetes, 51 2
E. Reich, H. Grafenstein, A. Barlow, K. Swenson, K. Williams, C. Janeway (1994)
Self peptides isolated from MHC glycoproteins of non-obese diabetic mice.
Journal of immunology, 152 5
E. Kawasaki, L. Yu, M. Rewers, J. Hutton, G. Eisenbarth (1998)
Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes.
Diabetes, 47 5
Balasubramanian Krishnamurthy, N. Dudek, M. McKenzie, A. Purcell, A. Brooks, S. Gellert, P. Colman, L. Harrison, A. Lew, H. Thomas, T. Kay (2006)
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.
The Journal of clinical investigation, 116 12
A. Suri, J. Walters, H. Rohrs, M. Gross, E. Unanue (2008)
First Signature of Islet β-Cell-Derived Naturally Processed Peptides Selected by Diabetogenic Class II MHC Molecules1
The Journal of Immunology, 180
R. Mukherjee, D. Wagar, T. Stephens, E. Lee‐Chan, Bhagirath Singh (2005)
Identification of CD4+ T Cell-Specific Epitopes of Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein: A Novel β Cell Autoantigen in Type 1 Diabetes1
The Journal of Immunology, 174
Kristin Melli, R. Friedman, A. Martin, E. Finger, G. Miao, G. Szot, M. Krummel, Q. Tang (2009)
Amplification of Autoimmune Response through Induction of Dendritic Cell Maturation in Inflamed Tissues1
The Journal of Immunology, 182
P. Halbout, J. Briand, C. Bécourt, S. Muller, C. Boitard (2002)
T Cell Response to Preproinsulin I and II in the Nonobese Diabetic Mouse1
The Journal of Immunology, 169
A. Suri, E. Unanue (2005)
The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection.
Advances in immunology, 88
J. Katz, Bo Wang, K. Haskins, C. Benoist, D. Mathis (1993)
Following a diabetogenic T cell from genesis through pathogenesis
Cell, 74
Balasubramanian Krishnamurthy, L. Mariana, S. Gellert, P. Colman, L. Harrison, A. Lew, P. Santamaria, H. Thomas, T. Kay (2008)
Autoimmunity to Both Proinsulin and IGRP Is Required for Diabetes in Nonobese Diabetic 8.3 TCR Transgenic Mice1
The Journal of Immunology, 180
R. Taubert, J. Schwendemann, B. Kyewski (2007)
Highly variable expression of tissue‐restricted self‐antigens in human thymus: Implications for self‐tolerance and autoimmunity
European Journal of Immunology, 37
D. Homann, T. Dyrberg, J. Petersen, M. Oldstone, M. Herrath (1999)
Insulin in oral immune "tolerance": a one-amino acid change in the B chain makes the difference.
Journal of immunology, 163 4
S. Singer, R. Tisch, X. Yang, H. Sytwu, R. Liblau, H. Mcdevitt (1998)
Prevention of diabetes in NOD mice by a mutated I-Ab transgene.
Diabetes, 47 10
R. Tisch, R. Liblau, Xiaodong Yang, Pascale Liblau, H. Mcdevitt (1998)
Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice.
Diabetes, 47 6
Audrey Seamons, Jennifer Sutton, Dina Bai, E. Baird, Nena Bonn, B. Kafsack, J. Shabanowitz, D. Hunt, C. Beeson, J. Goverman (2003)
Competition Between Two MHC Binding Registers in a Single Peptide Processed from Myelin Basic Protein Influences Tolerance and Susceptibility to Autoimmunity
The Journal of Experimental Medicine, 197
A. Quinn, Brigid McInerney, E. Reich, O. Kim, K. Jensen, E. Sercarz (2001)
Regulatory and Effector CD4 T Cells in Nonobese Diabetic Mice Recognize Overlapping Determinants on Glutamic Acid Decarboxylase and Use Distinct Vβ Genes1
The Journal of Immunology, 166
N. Abiru, D. Wegmann, E. Kawasaki, P. Gottlieb, E. Simone, G. Eisenbarth (2000)
Dual overlapping peptides recognized by insulin peptide B:9-23 T cell receptor AV13S3 T cell clones of the NOD mouse.
Journal of autoimmunity, 14 3
B. Coon, Ling-Ling An, J. Whitton, M. Herrath (1999)
DNA immunization to prevent autoimmune diabetes.
The Journal of clinical investigation, 104 2
C. Thivolet, A. Bendelac, Pierre Bedossa, Jean-Marie Bach, C. Carnaud (1991)
CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependent.
Journal of immunology, 146 1
B. Wentworth, I. Schaefer, L. Villa-komaroff, J. Chirgwin (2005)
Characterization of the two nonallelic genes encoding mouse preproinsulin
Journal of Molecular Evolution, 23
B. Calderon, Javier Carrero, Mark Miller, E. Unanue (2011)
Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans
Proceedings of the National Academy of Sciences, 108
Liping Yu, D. Robles, N. Abiru, P. Kaur, M. Rewers, Katalin Kelemen, G. Eisenbarth (2000)
Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes.
Proceedings of the National Academy of Sciences of the United States of America, 97 4
Masakazu Kobayashi, N. Abiru, T. Arakawa, K. Fukushima, Hongbo Zhou, E. Kawasaki, H. Yamasaki, E. Liu, D. Miao, F. Wong, G. Eisenbarth, K. Eguchi (2007)
Altered B:9–23 Insulin, When Administered Intranasally with Cholera Toxin Adjuvant, Suppresses the Expression of Insulin Autoantibodies and Prevents Diabetes1
The Journal of Immunology, 179
A. Bendelac, C. Carnaud, C. Boitard, J. Bach (1987)
Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells
The Journal of Experimental Medicine, 166
G. Bell, J. Karam, W. Rutter (1981)
Polymorphic DNA region adjacent to the 5' end of the human insulin gene.
Proceedings of the National Academy of Sciences of the United States of America, 78 9

Publisher: Annual Reviews
ISSN: 0732-0582
eISSN: 1545-3278
DOI: 10.1146/annurev-immunol-032712-095941
pmid: 24499272
Publisher site: See Article on Publisher Site

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Antigen Presentation in the Autoimmune Diabetes of the NOD Mouse

Antigen Presentation in the Autoimmune Diabetes of the NOD Mouse

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Antigen Presentation in the Autoimmune Diabetes of the NOD Mouse

Antigen Presentation in the Autoimmune Diabetes of the NOD Mouse

References (206)

Abstract

Journal

Recommended Articles

There are no references for this article.

Our policy towards the use of cookies