Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Antigen-Presenting Function of the Macrophage

Antigen-Presenting Function of the Macrophage In this review I deal with antigen presentation and focus primarily on the antigen-presenting function of the macrophage. The two main topics consid­ ered here are: (a) handling of antigen by the macrophage and the general concept of antigen processing"; and (b) the modulation of antigen-presenting cell (APC) function. In the latter section, I discuss APC other than the mac­ rophage. Because previous reviews (1,2) have considered in detail the inter­ actions between the macrophage and the T cell, I emphasize more recent studies here. The overwhelming evidence at present supports the following statements: (a) helper T cells are not activated by direct interactions of their receptors with soluble antigen; (b) the clones of helper T cells are activated by their interaction with antigen presented by an APC that must bear the Class II glycoproteins of the Major Histocompatibility Gene Complex (MHC) of the species-the Ia antigens; and (c) under physiological conditions of immuni­ zation, the clones of T cells and APC share the same allelic form of their Class II molecules. " ANTIGEN PROCESSING Three requirements are essential for a cell to function optimally in antigen presentation: the capacity to (a) express the Class II glycoproteins on http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Antigen-Presenting Function of the Macrophage

Unanue, E R
Annual Review of Immunology , Volume 2 (1) – Apr 1, 1984
Download PDF
34 pages

Loading next page...
 
/lp/annual-reviews/antigen-presenting-function-of-the-macrophage-sFE5zjkny0

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Annual Reviews
Copyright
Copyright 1984 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.02.040184.002143
pmid
6242349
Publisher site
See Article on Publisher Site

Abstract

In this review I deal with antigen presentation and focus primarily on the antigen-presenting function of the macrophage. The two main topics consid­ ered here are: (a) handling of antigen by the macrophage and the general concept of antigen processing"; and (b) the modulation of antigen-presenting cell (APC) function. In the latter section, I discuss APC other than the mac­ rophage. Because previous reviews (1,2) have considered in detail the inter­ actions between the macrophage and the T cell, I emphasize more recent studies here. The overwhelming evidence at present supports the following statements: (a) helper T cells are not activated by direct interactions of their receptors with soluble antigen; (b) the clones of helper T cells are activated by their interaction with antigen presented by an APC that must bear the Class II glycoproteins of the Major Histocompatibility Gene Complex (MHC) of the species-the Ia antigens; and (c) under physiological conditions of immuni­ zation, the clones of T cells and APC share the same allelic form of their Class II molecules. " ANTIGEN PROCESSING Three requirements are essential for a cell to function optimally in antigen presentation: the capacity to (a) express the Class II glycoproteins on

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1984

There are no references for this article.