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Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and... Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated di­ benzofurans (PCDFs) are members of a chemical family (polyhalogenated aromatics) that also includes the polychlorinated biphenyls, naphthalenes, azobenzenes, and azoxybenzenes, and the polybrominated biphenyls. In con­ trast to the polychlorinated biphenyls and naphthalenes and the polybrominated biphenyls, the PCDDs and PCDFs are not primary industrial products. PCDFs are found as by-products « 1 ppm) in commercial polychlorinated biphenyls and naphthalenes and are probably derived from dibenzofuran impurities in the industrial hydrocarbons that are subsequently chlorinated ( 1 -3). There is also circumstantial evidence that the effects of heat or arcing may produce PCDFs from polychlorinated biphenyls during use (4). This is evidenced by the relatively high levels of PCDFs (ca 100 ppm) detected in the polychlorinated biphenyl-containing heat transfer fluids that were the toxic agents in the Yusho disasters in Japan and Taiwan (3,5,6). PCDDs and PCDFs are also found as impurities in chlorinated phenols and their derived products (3, 7, 8), and it is apparent that the combustion of chlorinated aromatics and diverse types of chemical, industrial, and municipal waste results in the formation and release of these toxic chemicals into the environment (9-14). The potential for the 0362-1642/86/0415-0371$02.00 SAFE formation http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.26.040186.002103
pmid
3013079
Publisher site
See Article on Publisher Site

Abstract

Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated di­ benzofurans (PCDFs) are members of a chemical family (polyhalogenated aromatics) that also includes the polychlorinated biphenyls, naphthalenes, azobenzenes, and azoxybenzenes, and the polybrominated biphenyls. In con­ trast to the polychlorinated biphenyls and naphthalenes and the polybrominated biphenyls, the PCDDs and PCDFs are not primary industrial products. PCDFs are found as by-products « 1 ppm) in commercial polychlorinated biphenyls and naphthalenes and are probably derived from dibenzofuran impurities in the industrial hydrocarbons that are subsequently chlorinated ( 1 -3). There is also circumstantial evidence that the effects of heat or arcing may produce PCDFs from polychlorinated biphenyls during use (4). This is evidenced by the relatively high levels of PCDFs (ca 100 ppm) detected in the polychlorinated biphenyl-containing heat transfer fluids that were the toxic agents in the Yusho disasters in Japan and Taiwan (3,5,6). PCDDs and PCDFs are also found as impurities in chlorinated phenols and their derived products (3, 7, 8), and it is apparent that the combustion of chlorinated aromatics and diverse types of chemical, industrial, and municipal waste results in the formation and release of these toxic chemicals into the environment (9-14). The potential for the 0362-1642/86/0415-0371$02.00 SAFE formation

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1986

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