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Control by Drugs of Renal Potassium Handling

Control by Drugs of Renal Potassium Handling The kidney plays a major role in maintaining potassium homeostasis. In­ vestigations during the past thirty years have provided a great deal of informa­ tion about renal mechanisms involved in the regulation of potassium excretion. Much of this information is summarized in several recent reviews (1-3). Potassium undergoes both glomerular filtration and reabsorptive and secretory transport. Potassium is filtered freely in the large volumes of plasma that are filtered by the glomeruli and that course through the proximal portions of the nephron. Water, organic substances, and electrolytes are extensively reab­ sorbed from this ultrafiltrate of plasma so that 10% or less of the filtered volume emerges from the loop of Henle. Nearly all of the filtered potassium has been reabsorbed before the luminal fluid reaches the distal tubule. Potassium is added to the luminal fluid by cells of the distal tubule. As a consequence, the concentration of potassium in luminal fluid increases to levels that can exceed the plasma concentration by several fold. The potassium secreted from blood to luminal fluid by the distal cells accounts for most of the potassium that appears in the urine. The gradient for potassium generated in the distal tubule is maintained by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Control by Drugs of Renal Potassium Handling

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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.26.040186.001453
pmid
3521458
Publisher site
See Article on Publisher Site

Abstract

The kidney plays a major role in maintaining potassium homeostasis. In­ vestigations during the past thirty years have provided a great deal of informa­ tion about renal mechanisms involved in the regulation of potassium excretion. Much of this information is summarized in several recent reviews (1-3). Potassium undergoes both glomerular filtration and reabsorptive and secretory transport. Potassium is filtered freely in the large volumes of plasma that are filtered by the glomeruli and that course through the proximal portions of the nephron. Water, organic substances, and electrolytes are extensively reab­ sorbed from this ultrafiltrate of plasma so that 10% or less of the filtered volume emerges from the loop of Henle. Nearly all of the filtered potassium has been reabsorbed before the luminal fluid reaches the distal tubule. Potassium is added to the luminal fluid by cells of the distal tubule. As a consequence, the concentration of potassium in luminal fluid increases to levels that can exceed the plasma concentration by several fold. The potassium secreted from blood to luminal fluid by the distal cells accounts for most of the potassium that appears in the urine. The gradient for potassium generated in the distal tubule is maintained by

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1986

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