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Current Status and Prospects for Some Improved and New Bacterial Vaccines

Current Status and Prospects for Some Improved and New Bacterial Vaccines In this essay, we review some new bacterial vaccines, prospects for modifica­ tion and improvement of existing products, and the implication of recent insights into the pathogenic mechanisms of bacterial infection that may have an impact on the development of products for immunoprophylaxis. This subject has been recently reviewed (1-4). Innovation in the prevention of bacterial diseases by immunologic methods was in the doldrums for many years. Only two classes of bacterial vaccines were available until about a decade ago: toxoids for the prevention of toxin­ mediated diseases, namely diphtheria and tetanus toxoids, and whole-cell vaccines for the prevention of pertussis, typhoid, anthrax, and plague. The efficacy of whole-cell bacterial vaccines has been questioned, and their standardization and reproducibility of production have been difficult to achieve. An important advance in the prevention of bacterial diseases by immunologic methods evolved from the studies in the late 1930s by Felton and Macleod and their associates, using vaccines composed of the purified capsular polysacchar - · The US Government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. lOS ROBBINS & ROBBINS ides of pneumococci (5, 6). The advent of antibotics in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Public Health Annual Reviews

Current Status and Prospects for Some Improved and New Bacterial Vaccines

Robbins, F C; Robbins, J B
Annual Review of Public Health , Volume 7 (1) – May 1, 1986
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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0163-7525
eISSN
1545-2093
DOI
10.1146/annurev.pu.07.050186.000541
pmid
3521639
Publisher site
See Article on Publisher Site

Abstract

In this essay, we review some new bacterial vaccines, prospects for modifica­ tion and improvement of existing products, and the implication of recent insights into the pathogenic mechanisms of bacterial infection that may have an impact on the development of products for immunoprophylaxis. This subject has been recently reviewed (1-4). Innovation in the prevention of bacterial diseases by immunologic methods was in the doldrums for many years. Only two classes of bacterial vaccines were available until about a decade ago: toxoids for the prevention of toxin­ mediated diseases, namely diphtheria and tetanus toxoids, and whole-cell vaccines for the prevention of pertussis, typhoid, anthrax, and plague. The efficacy of whole-cell bacterial vaccines has been questioned, and their standardization and reproducibility of production have been difficult to achieve. An important advance in the prevention of bacterial diseases by immunologic methods evolved from the studies in the late 1930s by Felton and Macleod and their associates, using vaccines composed of the purified capsular polysacchar - · The US Government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. lOS ROBBINS & ROBBINS ides of pneumococci (5, 6). The advent of antibotics in the

Journal

Annual Review of Public Health – Annual Reviews

Published: May 1, 1986

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