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/lp/annual-reviews/differential-regulation-of-murine-t-lymphocyte-subsets-3RVPFkD24m
- Publisher
- Annual Reviews
- Copyright
- Copyright 1993 Annual Reviews. All rights reserved
- Subject
- Review Articles
- ISSN
- 0732-0582
- eISSN
- 1545-3278
- DOI
- 10.1146/annurev.iy.11.040193.000333
- pmid
- 8476563
- Publisher site
- See Article on Publisher Site
Abstract
Signaling pathways in T lymphocytes have been incompletely charac terized. It is evident that differences exist among the T cell subsets. We have defined several distinct mechanisms that affect differentially the activities of murine T lymphocyte clones representing various CD4+ and CD8+ sub sets: Interferon-y (IFN-y) inhibits proliferation of but not lymphokine production by TH2 cells. IL-lO inhibits antigen-presenting cell (APC) induced lymphokine production by T HI cells but not by TH2 cells. Murine THI and TH2 clones proliferate optimally in response to distinct APC populations. T HI and TH2 clones utilize different TCR-associated signaling pathways. High concentrations of antigen (or anti-TCR mAb) inhibit IL2-induced proliferation (but not lymphokine production) by THI and cytolytic T lymphocyte (CTL) clones only. Exposure of T HI clones (but not TH2 clones or CD8+ CTL clones) to IL-2 induces unresponsiveness to antigen. TH I and TH2 clones as well as CD8+ clones can be cytolytic, but not all T cells use the same cytolytic mechanisms. CD4+ clones from some mouse strains are not cytolytic if they do not secrete IFN-y. Under standing the mechanisms that differentially regulate the various kinds of T cells, in addition to providing insights into the molecular events
Journal
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1993