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Effector Mechanisms in Allograft Rejection

Effector Mechanisms in Allograft Rejection This review is divided into two parts. The first of these on the mechanism of allograft rejection concerns studies made with experimental animals and the second, the observations made in clinical transplantation. The experimental data relate mainly to the effector mechanisms of graft rejection but, because it is impossible to consider these without also considering how these effector mechanisms are called into play, a brief outline of present knowledge of the induction of the rejection process is also included. In humans, most immunological and histological observations have been made of patients with renal allografts, which are primarily vascularized tissue allografts where the rejection reaction has been modified by immunosuppressive therapy. Despite these differences from much of the experimental animal data, the interpretation of the human data is dependent on the experimental work and seems likely to remain so for some time. The need to understand the mechanisms by which an organ allograft is rejected in humans is essential for the design of better immunosuppressive therapy. 1 19 0732-0582/86/04 10-01 19$02.00 MASON & MORRIS EXPERIMENTAL The study of the immunological responses of laboratory animals to tissue or organ grafts from genetically dissimilar donors continues to be an active field http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Effector Mechanisms in Allograft Rejection

Mason, D W; Morris, P J
Annual Review of Immunology , Volume 4 (1) – Apr 1, 1986
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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.04.040186.001003
pmid
3518743
Publisher site
See Article on Publisher Site

Abstract

This review is divided into two parts. The first of these on the mechanism of allograft rejection concerns studies made with experimental animals and the second, the observations made in clinical transplantation. The experimental data relate mainly to the effector mechanisms of graft rejection but, because it is impossible to consider these without also considering how these effector mechanisms are called into play, a brief outline of present knowledge of the induction of the rejection process is also included. In humans, most immunological and histological observations have been made of patients with renal allografts, which are primarily vascularized tissue allografts where the rejection reaction has been modified by immunosuppressive therapy. Despite these differences from much of the experimental animal data, the interpretation of the human data is dependent on the experimental work and seems likely to remain so for some time. The need to understand the mechanisms by which an organ allograft is rejected in humans is essential for the design of better immunosuppressive therapy. 1 19 0732-0582/86/04 10-01 19$02.00 MASON & MORRIS EXPERIMENTAL The study of the immunological responses of laboratory animals to tissue or organ grafts from genetically dissimilar donors continues to be an active field

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1986

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